RTI-171

RTI-171
Identifiers
	IUPAC name 3-methyl-5-[(1S,3S,4S,5R)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-4-yl]-1,2-oxazole;
CAS Number	178929-75-4 ;
PubChem CID	10565888;
ChemSpider	8741276 ;
UNII	Q8U66P787F;
CompTox Dashboard (EPA)	DTXSID701029676 ;
Chemical and physical data
Formula	C19H24N2O
Molar mass	296.414 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES n1oc(cc1C)[C@@H]3[C@@H]4N(C)[C@H](C[C@@H]3c2ccc(cc2)C)CC4;
	InChI InChI=1S/C19H24N2O/c1-12-4-6-14(7-5-12)16-11-15-8-9-17(21(15)3)19(16)18-10-13(2)20-22-18/h4-7,10,15-17,19H,8-9,11H2,1-3H3/t15-,16+,17+,19-/m0/s1 ; Key:JWOFBAPJYPWTNI-FAJBIJEISA-N ;
	(what is this?) (verify)

(–)-2β-(3-Methylisoxazol-5-yl)-3β-(p-tolyl)tropane (RTI-4229-171) is a phenyltropane derivative which acts as a selective dopamine reuptake inhibitor, with a relatively slow onset of action and short duration of effects found in animal studies.^[1] However, other studies have shown it to have the most pronounced effects in terms of speed of onset and rate of stimulation among many differing phenyltropanes.^[2]

References

^ Kimmel HL, Carroll FI, Kuhar MJ (December 2001). "Locomotor stimulant effects of novel phenyltropanes in the mouse". Drug and Alcohol Dependence. 65 (1): 25–36. doi:10.1016/S0376-8716(01)00144-2. PMID 11714587.
^ Kimmel HL, O'Connor JA, Carroll FI, Howell LL (January 2007). "Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys". Pharmacology, Biochemistry, and Behavior. 86 (1): 45–54. doi:10.1016/j.pbb.2006.12.006. PMC 1850383. PMID 17258302.

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[pmid11714587-1] Kimmel HL, Carroll FI, Kuhar MJ (December 2001). "Locomotor stimulant effects of novel phenyltropanes in the mouse". Drug and Alcohol Dependence. 65 (1): 25–36. doi:10.1016/S0376-8716(01)00144-2. PMID 11714587.

[KimmelO'Connor2007-2] Kimmel HL, O'Connor JA, Carroll FI, Howell LL (January 2007). "Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys". Pharmacology, Biochemistry, and Behavior. 86 (1): 45–54. doi:10.1016/j.pbb.2006.12.006. PMC 1850383. PMID 17258302.

[1]

[2]

Identifiers

IUPAC name 3-methyl-5-[(1S,3S,4S,5R)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-4-yl]-1,2-oxazole
CAS Number	178929-75-4^Y
PubChem CID	10565888
ChemSpider	8741276^N
UNII	Q8U66P787F
CompTox Dashboard (EPA)	DTXSID701029676
Chemical and physical data
Formula	C₁₉H₂₄N₂O
Molar mass	296.414 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES n1oc(cc1C)[C@@H]3[C@@H]4N(C)[C@H](C[C@@H]3c2ccc(cc2)C)CC4
InChI InChI=1S/C19H24N2O/c1-12-4-6-14(7-5-12)16-11-15-8-9-17(21(15)3)19(16)18-10-13(2)20-22-18/h4-7,10,15-17,19H,8-9,11H2,1-3H3/t15-,16+,17+,19-/m0/s1^N Key:JWOFBAPJYPWTNI-FAJBIJEISA-N^N
^NY (what is this?) (verify)

RTI-171

See also

References