RTKN

Rhotekin is a protein that in humans is encoded by the RTKN gene.

RTKN
Identifiers
Aliases	RTKN, rhotekin
External IDs	OMIM: 602288; MGI: 107371; HomoloGene: 7522; GeneCards: RTKN; OMA:RTKN - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p13.1 Start 74,425,835 bp End 74,442,422 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 C3|6 35.94 cM Start 83,112,444 bp End 83,129,560 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment right lobe of liver tibial nerve sural nerve human kidney substantia nigra body of pancreas inferior ganglion of vagus nerve corpus callosum mucosa of transverse colon Top expressed in superior frontal gyrus lip primary visual cortex dentate gyrus of hippocampal formation granule cell internal carotid artery external carotid artery pontine nuclei right kidney lacrimal gland deep cerebellar nuclei More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding GTPase inhibitor activity protein binding Cellular component cytosol cellular component actomyosin contractile ring Biological process signal transduction apoptotic process negative regulation of GTPase activity regulation of apoptotic process Rho protein signal transduction septin cytoskeleton organization mitotic cytokinesis actomyosin contractile ring assembly cortical cytoskeleton organization septin ring organization protein localization to mitotic actomyosin contractile ring Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6242 20166 Ensembl ENSG00000114993 ENSMUSG00000034930 UniProt Q9BST9 Q8C6B2 RefSeq (mRNA) NM_001015055 NM_001015056 NM_033046 NM_001136227 NM_009106 NM_133641 NM_001355524 NM_001355525 RefSeq (protein) NP_001015055 NP_001015056 NP_149035 NP_001129699 NP_033132 NP_598396 NP_001342453 NP_001342454 Location (UCSC) Chr 2: 74.43 – 74.44 Mb Chr 6: 83.11 – 83.13 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Reid T, Furuyashiki T, Ishizaki T, et al. (1996). "Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain". J. Biol. Chem. 271 (23): 13556–60. doi:10.1074/jbc.271.23.13556. PMID 8662891.
• Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Fu Q, Yu L, Liu Q, et al. (2000). "Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286". Genomics. 66 (3): 328–32. doi:10.1006/geno.2000.6212. PMID 10873388.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sharfe N, Freywald A, Toro A, et al. (2003). "Ephrin stimulation modulates T cell chemotaxis". Eur. J. Immunol. 32 (12): 3745–55. doi:10.1002/1521-4141(200212)32:12<3745::AID-IMMU3745>3.0.CO;2-M. PMID 12516569.
• Katoh H, Negishi M (2003). "RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo". Nature. 424 (6947): 461–4. Bibcode:2003Natur.424..461K. doi:10.1038/nature01817. PMID 12879077. S2CID 4411133.
• Liu CA, Wang MJ, Chi CW, et al. (2005). "Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma". J. Biomed. Sci. 11 (5): 661–70. doi:10.1159/000079679. PMID 15316142. S2CID 23706370.
• Jacinto E, Loewith R, Schmidt A, et al. (2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive". Nat. Cell Biol. 6 (11): 1122–8. doi:10.1038/ncb1183. PMID 15467718. S2CID 13831153.
• Liu CA, Wang MJ, Chi CW, et al. (2005). "Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis". Oncogene. 23 (54): 8731–42. doi:10.1038/sj.onc.1208106. PMID 15480428. S2CID 34744906.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fan J, Ma LJ, Xia SJ, et al. (2005). "Association between clinical characteristics and expression abundance of RTKN gene in human bladder carcinoma tissues from Chinese patients". J. Cancer Res. Clin. Oncol. 131 (3): 157–62. doi:10.1007/s00432-004-0638-8. PMID 15599595. S2CID 20172785.
• Fernandez-Zapico ME, Gonzalez-Paz NC, Weiss E, et al. (2005). "Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis". Cancer Cell. 7 (1): 39–49. doi:10.1016/j.ccr.2004.11.024. PMID 15652748.
• Park JB, Yiu G, Kaneko S, et al. (2005). "A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors". Neuron. 45 (3): 345–51. doi:10.1016/j.neuron.2004.12.040. PMID 15694321. S2CID 86746993.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Satchi-Fainaro R, Mamluk R, Wang L, et al. (2005). "Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin". Cancer Cell. 7 (3): 251–61. doi:10.1016/j.ccr.2005.02.007. PMID 15766663.
• Kukar T, Murphy MP, Eriksen JL, et al. (2005). "Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production". Nat. Med. 11 (5): 545–50. doi:10.1038/nm1235. PMID 15834426. S2CID 7002047.
• Kiyan J, Kiyan R, Haller H, Dumler I (2005). "Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta". EMBO J. 24 (10): 1787–97. doi:10.1038/sj.emboj.7600669. PMC 1142599. PMID 15889147.
• Ito H, Iwamoto I, Morishita R, et al. (2005). "Possible role of Rho/Rhotekin signaling in mammalian septin organization". Oncogene. 24 (47): 7064–72. doi:10.1038/sj.onc.1208862. PMID 16007136. S2CID 24204558.