Relaxin/insulin-like family peptide receptor 2

Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human G-protein coupled receptor.

RXFP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M96
Identifiers
Aliases	RXFP2, GPR106, GREAT, INSL3R, LGR8, LGR8.1, RXFPR2, Relaxin/insulin-like family peptide receptor 2, relaxin/insulin like family peptide receptor 2, relaxin family peptide receptor 2
External IDs	OMIM: 606655; MGI: 2153463; HomoloGene: 15402; GeneCards: RXFP2; OMA:RXFP2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q13.1 Start 31,739,526 bp End 31,803,389 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 G3|5 89.23 cM Start 149,942,140 bp End 150,005,649 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle monocyte granulocyte gonad left uterine tube blood smooth muscle tissue right adrenal cortex left adrenal gland left adrenal cortex Top expressed in mesothelium spermatocyte mesothelium of peritoneum spermatid seminiferous tubule embryo embryo vas deferens genital tubercle abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function protein-hormone receptor activity signal transducer activity G protein-coupled receptor activity peptide hormone binding G protein-coupled peptide receptor activity Cellular component integral component of membrane membrane plasma membrane intracellular anatomical structure integral component of plasma membrane Biological process male gonad development negative regulation of apoptotic process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway oocyte maturation signal transduction negative regulation of cell population proliferation adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway positive regulation of cAMP-mediated signaling activation of adenylate cyclase activity hormone-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 122042 140498 Ensembl ENSG00000133105 ENSMUSG00000053368 UniProt Q8WXD0 Q91ZZ5 RefSeq (mRNA) NM_001166058 NM_130806 NM_001289564 NM_001289566 NM_080468 RefSeq (protein) NP_001159530 NP_570718 NP_001276493 NP_001276495 NP_536716 Location (UCSC) Chr 13: 31.74 – 31.8 Mb Chr 5: 149.94 – 150.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The receptors for glycoprotein hormones such as follicle-stimulating hormone (FSH; see MIM 136530) and thyroid-stimulating hormone (TSH; see MIM 188540) are G protein-coupled, 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains. Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily. [supplied by OMIM].

See also

• Relaxin receptor

Further reading

• Bathgate RA, Ivell R, Sanborn BM, et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci. 1041 (1): 61–76. Bibcode:2005NYASA1041...61B. doi:10.1196/annals.1282.010. PMID 15956688. S2CID 1185573.
• Bathgate RA, Ivell R, Sanborn BM, et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. S2CID 7466039.
• Hsu SY, Nakabayashi K, Nishi S, et al. (2002). "Activation of orphan receptors by the hormone relaxin". Science. 295 (5555): 671–4. Bibcode:2002Sci...295..671H. doi:10.1126/science.1065654. PMID 11809971. S2CID 32693420.
• Kumagai J, Hsu SY, Matsumi H, et al. (2002). "INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent". J. Biol. Chem. 277 (35): 31283–6. doi:10.1074/jbc.C200398200. PMID 12114498.
• Gorlov IP, Kamat A, Bogatcheva NV, et al. (2003). "Mutations of the GREAT gene cause cryptorchidism". Hum. Mol. Genet. 11 (19): 2309–18. doi:10.1093/hmg/11.19.2309. PMID 12217959.
• Sudo S, Kumagai J, Nishi S, et al. (2003). "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2". J. Biol. Chem. 278 (10): 7855–62. doi:10.1074/jbc.M212457200. PMID 12506116.
• Ferlin A, Simonato M, Bartoloni L, et al. (2003). "The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism". J. Clin. Endocrinol. Metab. 88 (9): 4273–9. doi:10.1210/jc.2003-030359. PMID 12970298.
• Roh J, Virtanen H, Kumagai J, et al. (2004). "Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism". Reprod. Biomed. Online. 7 (4): 400–6. doi:10.1016/S1472-6483(10)61883-4. PMID 14656401.
• Vinci G, Anjot MN, Trivin C, et al. (2005). "An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia". J. Clin. Endocrinol. Metab. 89 (12): 6282–5. doi:10.1210/jc.2004-0891. PMID 15579790.
• Büllesbach EE, Schwabe C (2005). "LGR8 signal activation by the relaxin-like factor". J. Biol. Chem. 280 (15): 14586–90. doi:10.1074/jbc.M414443200. PMID 15708846.
• Muda M, He C, Martini PG, et al. (2005). "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity". Mol. Hum. Reprod. 11 (8): 591–600. doi:10.1093/molehr/gah205. PMID 16051677.
• Rosengren KJ, Zhang S, Lin F, et al. (2006). "Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3". J. Biol. Chem. 281 (38): 28287–95. doi:10.1074/jbc.M603829200. PMID 16867980.
• Bogatcheva NV, Ferlin A, Feng S, et al. (2007). "T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane". Am. J. Physiol. Endocrinol. Metab. 292 (1): E138–44. doi:10.1152/ajpendo.00228.2006. PMID 16926383. S2CID 17442101.
• Scott DJ, Layfield S, Yan Y, et al. (2007). "Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules". J. Biol. Chem. 281 (46): 34942–54. doi:10.1074/jbc.M602728200. PMID 16963451.
• El Houate B, Rouba H, Sibai H, et al. (2007). "Novel mutations involving the INSL3 gene associated with cryptorchidism". J. Urol. 177 (5): 1947–51. doi:10.1016/j.juro.2007.01.002. PMID 17437853.
• Scott DJ, Wilkinson TN, Zhang S, et al. (2007). "Defining the LGR8 residues involved in binding insulin-like peptide 3". Mol. Endocrinol. 21 (7): 1699–712. doi:10.1210/me.2007-0097. PMID 17473281.

External links

• "Relaxin Family Peptide Receptors: RXFP2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.