The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.[1][2]
| relaxin/insulin-like family peptide receptor 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RXFP1 | ||||||
| Alt. symbols | LGR7 | ||||||
| NCBI gene | 59350 | ||||||
| HGNC | 19718 | ||||||
| OMIM | 606654 | ||||||
| RefSeq | NM_021634 | ||||||
| UniProt | Q9HBX9 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q31.3 | ||||||
| |||||||
| relaxin/insulin-like family peptide receptor 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RXFP2 | ||||||
| Alt. symbols | LGR8, GREAT, GPR106, INSL3R | ||||||
| NCBI gene | 122042 | ||||||
| HGNC | 17318 | ||||||
| OMIM | 606655 | ||||||
| RefSeq | NM_130806 | ||||||
| UniProt | Q8WXD0 | ||||||
| Other data | |||||||
| Locus | Chr. 13 q12.3 | ||||||
| |||||||
| relaxin/insulin-like family peptide receptor 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RXFP3 | ||||||
| Alt. symbols | RLN3R1, SALPR, GPCR135 | ||||||
| NCBI gene | 51289 | ||||||
| HGNC | 24883 | ||||||
| OMIM | 609445 | ||||||
| RefSeq | NM_016568 | ||||||
| UniProt | Q9NSD7 | ||||||
| Other data | |||||||
| Locus | Chr. 5 p15.1-p14 | ||||||
| |||||||
| relaxin/insulin-like family peptide receptor 4 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RXFP4 | ||||||
| Alt. symbols | GPR100, GPCR142, RLN3R2 | ||||||
| NCBI gene | 339403 | ||||||
| HGNC | 14666 | ||||||
| OMIM | 609043 | ||||||
| RefSeq | NM_181885 | ||||||
| UniProt | Q8TDU9 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q22 | ||||||
| |||||||
Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.
| receptor/gene | ligands | activates | inhibits |
|---|---|---|---|
| RXFP1 | relaxin 1, relaxin 2, relaxin 3 | adenylate cyclase, protein kinase A, protein kinase C,
phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2) |
|
| RXFP2 | relaxin 1, relaxin 2, insulin-like 3 | adenylate cyclase | |
| RXFP3 | relaxin 3 | Erk1/2 signaling | adenylate cyclase |
| RXFP4 | relaxin 3, insulin-like 3 | adenylate cyclase |
See also
editReferences
edit- ^ Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. S2CID 7466039.
- ^ Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ (2007). "Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways". Br. J. Pharmacol. 150 (6): 677–91. doi:10.1038/sj.bjp.0707140. PMC 2013861. PMID 17293890.
External links
edit- "Relaxin Family Peptide Receptors: Motilin". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
- relaxin+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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