Relaxin/insulin-like family peptide receptor 3

Relaxin/insulin-like family peptide receptor 3, also known as RXFP3, is a human G-protein coupled receptor.

RXFP3
Identifiers
Aliases	RXFP3, GPCR135, RLN3R1, RXFPR3, SALPR, Relaxin/insulin-like family peptide receptor 3, relaxin/insulin like family peptide receptor 3, relaxin family peptide receptor 3
External IDs	OMIM: 609445; MGI: 2441827; HomoloGene: 9568; GeneCards: RXFP3; OMA:RXFP3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5p13.2 Start 33,936,386 bp End 33,938,918 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 A1 Start 11,033,803 bp End 11,038,077 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans right adrenal cortex left adrenal cortex prefrontal cortex superior frontal gyrus anterior pituitary hypothalamus caudate nucleus substantia nigra head Top expressed in embryo dentate gyrus of hippocampal formation granule cell embryo hippocampus proper hypothalamus visual cortex neural tube mesencephalon neural layer of retina primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity galanin receptor activity G protein-coupled peptide receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process positive regulation of cytokinesis G protein-coupled receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51289 239336 Ensembl ENSG00000182631 ENSG00000277069 ENSMUSG00000060735 UniProt Q9NSD7 Q8BGE9 RefSeq (mRNA) NM_016568 NM_178717 RefSeq (protein) NP_057652 NP_848832 Location (UCSC) Chr 5: 33.94 – 33.94 Mb Chr 15: 11.03 – 11.04 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Relaxin receptor

Further reading

• Bathgate RA, Ivell R, Sanborn BM, et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci. 1041 (1): 61–76. Bibcode:2005NYASA1041...61B. doi:10.1196/annals.1282.010. PMID 15956688. S2CID 1185573.
• Bathgate RA, Ivell R, Sanborn BM, et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. S2CID 7466039.
• Matsumoto M, Kamohara M, Sugimoto T, et al. (2000). "The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors". Gene. 248 (1–2): 183–9. doi:10.1016/S0378-1119(00)00123-2. PMID 10806363.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu C, Eriste E, Sutton S, et al. (2004). "Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135". J. Biol. Chem. 278 (50): 50754–64. doi:10.1074/jbc.M308995200. PMID 14522968.
• Liu C, Chen J, Kuei C, et al. (2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Mol. Pharmacol. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925. S2CID 25164369.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Van der Westhuizen ET, Sexton PM, Bathgate RA, Summers RJ (2005). "Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry". Ann. N. Y. Acad. Sci. 1041 (1): 332–7. Bibcode:2005NYASA1041..332V. doi:10.1196/annals.1282.053. PMID 15956730. S2CID 2468316.

External links

• "Relaxin Family Peptide Receptors: RXFP3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.