Ralph Isadore Dorfman (1911–1985) was a Jewish-American biochemist. His work on metabolism in pharmacology and the use of steroid hormones contributed to the development of the combined oral contraceptive pill.[1]
Ralph Dorfman | |
|---|---|
| Born | Ralph Isadore Dorfman June 30, 1911 Chicago, Illinois |
| Died | November 19, 1985 (aged 74) |
| Education | University of Illinois, University of Chicago |
| Known for | Combined oral contraceptive pill |
| Awards | National Academy of Sciences |
| Scientific career | |
| Fields | Biochemistry, pharmacology |
| Institutions | Yale University, Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts; Syntex Research, Palo Alto, California; Stanford University |
Dorfman was born in Chicago, Illinois.[2] He received his bachelor's degree from the University of Illinois and a doctorate from the University of Chicago.[1] After teaching at several institutions, including Yale University, he became a director at the Worcester Foundation for Experimental Biology in Shrewsbury, Massachusetts, which, during his 13-year tenure there, "became an international center for bioassays and the study of the chemistry, biochemistry, and biology of steroid hormones."[2]
While working at the Worcester Foundation, Dorfman was a research consultant to the Syntex Corporation, starting in 1950. There he helped to develop the first publicly available birth control pill.[2] In 1964, Dorfman joined Syntex full-time, eventually serving as president of Syntex Research in Palo Alto, California from 1973 to 1976.[1] Dorfman's research also focused on treatments for cancer and rheumatoid arthritis and originated the reproductive biology concept of anti-estrogens and anti-androgens.[2]
Late in his career, Dorfman returned to academia serving as a visiting professor in the Department of Molecular Pharmacology at Stanford University, 1967–1973, and finally as a consulting professor until his death. In addition to his numerous papers, Dorfman was the author or editor of 14 books and founded the journal Steroids.[3]
Dorfman died of complications of Parkinson's disease at El Camino Hospital in Mountain View, California, at the age of 74.[1] His brother was Albert Dorfman,[2] and his grandson is Barnaby Dorfman.
References
edit- ^ a b c d "Dr. Ralph I. Dorfman", The New York Times, December 12, 1985, accessed February 5, 2019
- ^ a b c d e Simoni, Robert D., Robert L. Hill, Martha Vaughan and Herbert Tabor. "The Metabolism of Steroid Hormones: Ralph I. Dorfman", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, December 12, 2003
- ^ "Ralph I. Dorfman Lectureship", Stanford Medicine, Stanford University, accessed February 5, 2018