RAC otherwise known as Repository of Antibiotic resistance Cassettes is a database that uses the automatic Attacca annotation system in order to comprehensively annotate gene-cassettes and transposable elements in a stream-lined manner and to discover novel gene cassettes.[1] Antibiotic resistance is often due to horizontal gene transfer, which allows resistance to arise through cell-to-cell interaction.[2] This poses a major challenge in the field of antibiotic resistance. Hence, the creation of RAC which would provide researchers a comprehensive and unique tool for the endeavor of documenting resistance due to gene-cassettes and transposable elements. Attacca helps discover novel gene cassettes when any three of the following occurs as mentioned in Tsafnat et al, 2011:
- the Attacca discovery heuristics (19) identify a gap in a cassette array that could correspond to a novel cassette;[1]
- a cassette encoding a potentially novel β-lactamase variant is detected;[1] or
- the type of sequence submitted (e.g. isolated cassette) suggests that a gene cassette should be present but a gene cassette is not found by Attacca.[1]
| Content | |
|---|---|
| Description | Database focused on the discovery and annotation of novel gene cassettes and other transposable elements. |
| Data types captured | Gene Cassettes and Transposable elements |
| Organisms | Bacteria |
| Contact | |
| Primary citation | PMID 22140215 |
| Access | |
| Website | www2 |
| Miscellaneous | |
| Bookmarkable entities | yes |
If any of these cases occur, the gene-cassette would be sent to review at the Centre for Infectious Diseases and Microbiology, University of Sydney for further examination.[1]
See also
editReferences
edit- ^ a b c d e Tsafnat, G.; Copty, J.; Partridge, S. R. (2011-12-02). "RAC: Repository of Antibiotic resistance Cassettes". Database. 2011: bar054. doi:10.1093/database/bar054. ISSN 1758-0463. PMC 3229207. PMID 22140215.
- ^ Stokes, Hatch W.; Gillings, Michael R. (September 2011). "Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens". FEMS Microbiology Reviews. 35 (5): 790–819. doi:10.1111/j.1574-6976.2011.00273.x. ISSN 1574-6976. PMID 21517914.
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