Resistance Is Futile may refer to:

  • Resistance Is Futile (Oh Hiroshima), a 2012 studio album by Oh Hiroshima
  • Resistance Is Futile (album), a 2018 studio album by the Manic Street Preachers
  • Resistance Is Futile!, a 2018 book by Ann Coulter
  • "Resistance is futile", a phrase spoken in the 1977 episode "The Dorcons" of the TV show Space: 1999
  • "Resistance Is Futile" (Dexter), a 2007 broadcast episode of Dexter
  • "Resistance is futile", a phrase uttered by the Borg in Star Trek
  • Apparently, the phrase "resistance is futile" appeared the first time on TV in a 1967 "Doctor Who" episode called "Tomb of the Cybermen".
  • "Resistance would be futile", a phrase spoken in episode of "Lost in Space (1965)" titled "Wreck of the Robot" that aired on Dec 14, 1966.