Retinoic acid-inducible orphan G protein-coupled receptor

G protein coupled receptor, family C, group 5, member B
G protein coupled receptor, family C, group 5, member B
Identifiers
Symbol	GPRC5B
Alt. symbols	RAIG2
NCBI gene	51704
HGNC	13308
OMIM	605948
RefSeq	NM_016235
UniProt	Q9NZH0
Other data
Locus	Chr. 16 p12
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

G protein-coupled receptor, family C, group 5, member A
G protein-coupled receptor, family C, group 5, member A
Identifiers
Symbol	GPRC5A
Alt. symbols	RAIG1, RAI3
NCBI gene	9052
HGNC	9836
OMIM	604138
RefSeq	NM_003979
UniProt	Q8NFJ5
Other data
Locus	Chr. 12 p13-p12.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.^[1]^[2]^[3]^[4]

G protein-coupled receptor, family C, group 5, member C

Identifiers

Symbol

GPRC5C

Alt. symbols

RAIG3

Other data

Chr. 17 q25

Search for
Structures	Swiss-model
Domains	InterPro

G protein-coupled receptor, family C, group 5, member D

Identifiers

Symbol

GPRC5D

Other data

Chr. 12 p13.3

Search for
Structures	Swiss-model
Domains	InterPro

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.^[5]

References

^ Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.
^ Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
^ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
^ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta. 1518 (3): 237–48. doi:10.1016/s0167-4781(01)00197-x. PMID 11311935.
^ Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). "Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling". Biochem. Biophys. Res. Commun. 358 (4): 968–75. doi:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.

External links

"GPRC5 (RAIG) Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
GPRC5A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
GPRC5B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
GPRC5C+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[pmid9857033-1] Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.

[pmid10783259-2] Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.

[pmid10945465-3] Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.

[pmid11311935-4] Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta. 1518 (3): 237–48. doi:10.1016/s0167-4781(01)00197-x. PMID 11311935.

[pmid17521608-5] Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). "Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling". Biochem. Biophys. Res. Commun. 358 (4): 968–75. doi:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.

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