Ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-(BtrI acyl-carrier protein) 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase
Ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-(BtrI acyl-carrier protein) 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase (EC 2.3.2.19, btrH (gene)) is an enzyme with systematic name ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-(BtrI acyl-carrier protein) 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase.[1] This enzyme catalyses the following chemical reaction
| Ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-(BtrI acyl-carrier protein) 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate transferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.2.19 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + ribostamycin gamma-L-glutamyl-butirosin B + BtrI acyl-carrier protein
The enzyme attaches the side chain of the aminoglycoside antibiotics of the butirosin family.
References
edit- ^ Llewellyn NM, Li Y, Spencer JB (April 2007). "Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain". Chemistry & Biology. 14 (4): 379–86. doi:10.1016/j.chembiol.2007.02.005. PMID 17462573.
External links
edit- Ribostamycin:4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoyl-(BtrI+acyl-carrier+protein)+4-(gamma-L-glutamylamino)-(S)-2-hydroxybutanoate+transferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
