In enzymology, a ribosylnicotinamide kinase (EC 2.7.1.22) is an enzyme that catalyzes the chemical reaction
| ribosylnicotinamide kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.22 | ||||||||
| CAS no. | 9030-61-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- ATP + N-ribosylnicotinamide ADP + nicotinamide ribonucleotide
Thus, the two substrates of this enzyme are ATP and N-ribosylnicotinamide, whereas its two products are ADP and nicotinamide ribonucleotide.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-ribosylnicotinamide 5'-phosphotransferase. This enzyme is also called ribosylnicotinamide kinase (phosphorylating). This enzyme participates in nicotinate and nicotinamide metabolism.
Health
editStudies show potential for obesity treatment and for longer healthier life. Ribosylnicotinamide kinase seems to activate similar genes that Resveratrol does.[citation needed]
Food
editThe enzyme can be found in milk[1] and beer. Since the molecules are difficult to detect, it is expected that there are a lot more food products containing ribosylnicotinamide kinase.
References
edit- ^ Bieganowski, Pawel & Brenner, Charles. (2004). Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans. Cell. 117. 495-502. 10.1016/S0092-8674(04)00416-7.
- ROWEN JW, KORNBERG A (1951). "The phosphorolysis of nicotinamide riboside". J. Biol. Chem. 193 (2): 497–507. PMID 14907738.
