Rifasutenizol

Rifasutenizol
Identifiers
	IUPAC name [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-[2-(2-methyl-5-nitroimidazol-1-yl)ethyl]-6,23-dioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(31),2,4,9,19,21,25(32),26,29-nonaene-28,4'-piperidine]-13-yl] acetate;
CAS Number	1001314-13-1;
PubChem CID	136014272;
UNII	2G83RZK9U6;
ChEMBL	ChEMBL5172403;
Chemical and physical data
Formula	C48H61N7O13
Molar mass	944.052 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]1/C=C/C=C(\C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C5=NC6(CCN(CC6)CCN7C(=NC=C7[N+](=O)[O-])C)N=C25)O)/C;
	InChI InChI=InChI=1S/C48H61N7O13/c1-23-12-11-13-24(2)46(62)50-38-37-36(51-48(52-37)15-17-53(18-16-48)19-20-54-29(7)49-22-32(54)55(63)64)33-34(42(38)60)41(59)28(6)44-35(33)45(61)47(9,68-44)66-21-14-31(65-10)25(3)43(67-30(8)56)27(5)40(58)26(4)39(23)57/h11-14,21-23,25-27,31,39-40,43,57-60H,15-20H2,1-10H3,(H,50,62)/b12-11+,21-14+,24-13-/t23-,25+,26+,27+,31-,39-,40+,43+,47-/m0/s1; Key:OZUTUJQHZGJOKZ-AIGATTFSSA-N;

Rifasutenizol is an investigational new drug developed by TenNor Therapeutics, primarily aimed at treating Helicobacter pylori infections.^[1] It is a novel multi-targeting small molecule that functions as a bacterial DNA-directed RNA polymerase inhibitor.^[2] This drug has been granted Qualified Infectious Disease Product and Fast Track designations by the U.S. FDA.^[3]^[4]^[5]

References

^ "Rifasutenizol - TenNor Therapeutics". AdisInsight. Springer Nature Switzerland AG.
^ Li X, Liu Y, Wang M, Gao L, Liu J, Zhang H, et al. (June 2024). "Safety, pharmacokinetics, and efficacy of rifasutenizol, a novel dual-targeted antibacterial agent in healthy participants and patients in China with Helicobacter pylori infection: four randomised clinical trials". The Lancet. Infectious Diseases. 24 (6): 650–664. doi:10.1016/S1473-3099(24)00003-3. PMID 38359854.
^ "TenNor Announces Positive Topline Results from Rifasutenizol Phase III Trial for H. pylori Infection". Retrieved 24 November 2024.
^ "Efficacy and Safety of Rifasutenizol (TNP 2198) in Participants With H. pylori Infection". Retrieved 24 November 2024.
^ "Rifasutenizol - Drug Targets, Indications, Patents - Patsnap Synapse". Retrieved 24 November 2024.

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Identifiers

IUPAC name [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-[2-(2-methyl-5-nitroimidazol-1-yl)ethyl]-6,23-dioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(31),2,4,9,19,21,25(32),26,29-nonaene-28,4'-piperidine]-13-yl] acetate
CAS Number	1001314-13-1
PubChem CID	136014272
UNII	2G83RZK9U6
ChEMBL	ChEMBL5172403
Chemical and physical data
Formula	C₄₈H₆₁N₇O₁₃
Molar mass	944.052 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@H]1/C=C/C=C(\C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C5=NC6(CCN(CC6)CCN7C(=NC=C7[N+](=O)[O-])C)N=C25)O)/C
InChI InChI=InChI=1S/C48H61N7O13/c1-23-12-11-13-24(2)46(62)50-38-37-36(51-48(52-37)15-17-53(18-16-48)19-20-54-29(7)49-22-32(54)55(63)64)33-34(42(38)60)41(59)28(6)44-35(33)45(61)47(9,68-44)66-21-14-31(65-10)25(3)43(67-30(8)56)27(5)40(58)26(4)39(23)57/h11-14,21-23,25-27,31,39-40,43,57-60H,15-20H2,1-10H3,(H,50,62)/b12-11+,21-14+,24-13-/t23-,25+,26+,27+,31-,39-,40+,43+,47-/m0/s1 Key:OZUTUJQHZGJOKZ-AIGATTFSSA-N