Ring finger protein 103

RNF103
Identifiers
Aliases	RNF103, HKF-1, KF-1, KF1, ZFP-103, ZFP103, ring finger protein 103
External IDs	OMIM: 602507; MGI: 109483; HomoloGene: 4146; GeneCards: RNF103; OMA:RNF103 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	86,623,866 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	71,487,865 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; amniotic fluid; ; corpus epididymis; ; jejunal mucosa; ; Brodmann area 23; ; mucosa of ileum; ; germinal epithelium; ; trigeminal ganglion; ; corpus callosum; ; paraflocculus of cerebellum;
	Top expressed in
	left colon; ; ciliary body; ; conjunctival fornix; ; seminal vesicula; ; substantia nigra; ; lacrimal gland; ; parotid gland; ; lobe of prostate; ; stroma of bone marrow; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin-protein transferase activity; transferase activity; ubiquitin protein ligase activity;
Cellular component	integral component of membrane; endoplasmic reticulum; membrane; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment;
Biological process	central nervous system development; protein ubiquitination; ubiquitin-dependent ERAD pathway; endoplasmic reticulum mannose trimming;
	Sources:Amigo / QuickGO
Orthologs
	7844
	22644
	ENSG00000239305
	ENSMUSG00000052656
	O00237
	Q9R1W3
	NM_005667; NM_001198951; NM_001198952
	NM_009543; NM_001308303
	NP_001185880; NP_001185881; NP_005658
	NP_001295232; NP_033569
	Wikidata
View/Edit Human	View/Edit Mouse

Ring finger protein 103 is a protein that in humans is encoded by the RNF103 gene. ^[5]

Function

The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by electroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000239305 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052656 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Ring finger protein 103". Retrieved 2017-07-04.

Ring finger protein 103

Function

References

Further reading