The rixosome is a protein complex involved in RNA degradation, ribosomal RNA (rRNA) processing, and ribosome biogenesis. It was named after the S. cerevisiae gene RIX1.[1][2] The rixosome is associated with human PRC1 and PRC2 complexes. The interaction with PRC1 appears to be through the RING1B domain of PRC1 based on mutational analysis. The co-localization of the rixosome and PRC complex suggest a role in the rixosomal degradation of nascent RNA to contribute to the silencing of many Polycomb targets in human cells.[3] Regulation of the interaction with the PRC1 complex is mediated by SENP3 which deSUMOylates several rixosome subunits.[4]
Components
editRixosome complex contains the following components:
References
edit- ^ Castle CD, Cassimere EK, Denicourt C (February 2012). "LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis". Molecular Biology of the Cell. 23 (4): 716–728. doi:10.1091/mbc.E11-06-0530. PMC 3279398. PMID 22190735.
- ^ Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D (June 2020). "A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin". eLife. 9. doi:10.7554/eLife.54341. PMC 7269676. PMID 32491985.
- ^ Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, et al. (April 2022). "Rixosomal RNA degradation contributes to silencing of Polycomb target genes". Nature. 604 (7904): 167–174. Bibcode:2022Natur.604..167Z. doi:10.1038/s41586-022-04598-0. PMC 8986528. PMID 35355014. S2CID 247842006.
- ^ Zhou H, Feng W, Yu J, Shafiq TA, Paulo JA, Zhang J; et al. (2023). "SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions". Cell Rep. 42 (4): 112339. doi:10.1016/j.celrep.2023.112339. PMC 10777863. PMID 37014752.
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