Route 59 may refer to:
- Route 59 (MTA Maryland), a bus route in Baltimore, Maryland and its suburbs
- London Buses route 59
- Melbourne tram route 59
- SEPTA Route 59, a trackless trolley in Northeast Philadelphia
- Route 59 (Metra), a train station along the BNSF Railway Line on the border of Aurora, Illinois and Naperville, Illinois
See also
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This disambiguation page lists articles associated with the title Route 59.
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