In genetics, rs28363170 (DAT1-VNTR) is a genetic variation at SLC6A3, the gene that encodes the dopamine transporter. It is polymorphism as a 40 base pairs VNTR in the 3' untranslated region. It is a deletion/insertion polymorphism (DIP).[1]
| SNP: rs28363170 | |
|---|---|
| Gene | SLC6A3 |
| Chromosome | 5 |
| External databases | |
| Ensembl | Human SNPView |
| dbSNP | 28363170 |
| HapMap | 28363170 |
| SNPedia | 28363170 |
The 9-repeat and the 10-repeat are the most common alleles.[2]
References
edit- ^ "Rs28363170 RefSNP Report - DBSNP - NCBI".
- ^ David Mrazek (2010). Psychiatric Pharmacogenomics. Oxford University Press.
Further
edit- A. Sano; K. Kondoh; Y. Kakimoto (May 1993). "A 40-nucleotide repeat polymorphism in the human dopamine transporter gene". Human Genetics. 91 (4): 405–406. doi:10.1007/BF00217369. PMID 8500798. S2CID 39416578.
- Joober, R.; Grizenko, N; Sengupta, S; Amor, LB; Schmitz, N; Schwartz, G; Karama, S; Lageix, P; et al. (2007). "Dopamine transporter 3'-UTR VNTR genotype and ADHD: a pharmaco-behavioural genetic study with methylphenidate". Neuropsychopharmacology. 32 (6): 1370–1376. doi:10.1038/sj.npp.1301240. PMID 17063150. S2CID 2944059.