Rukhadze (Georgian: რუხაძე) is a Georgian surname. Notable people with the surname include:
- David Rukhadze (born 1963), Georgian footballer
- Irakli Rukhadze, Georgian footballer
- Otar Rukhadze, Georgian doctor
- Zurab Rukhadze (born 2003), Georgian footballer
- Henri Rukhadze (1930–2018), Soviet and Russian physicist