Rzayev or Rzaev (Russian: Рзаев) is an Azerbaijani masculine surname, its feminine counterpart is Rzayeva or Rzaeva. It may refer to
- Anar Rzayev (born 1938), Azerbaijani writer, dramatist and film director
- Dadash Rzayev (born 1935), Minister of Defense of Azerbaijan
- Hagigat Rzayeva (1907–1969), Azerbaijani actress and singer
- Mushig Rzayev (born 1998), Azerbaijani football player
- Rail Rzayev (1945–2009), Commander of the Azerbaijani Air Force
- Ruslan Rzayev (born 1998), Russian football player
- Vidadi Rzayev (born 1967), Azerbaijani football midfielder