S-309309

S-309309
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name N-[(4R)-5,7-difluoro-2'-(5-methylpyridin-2-yl)-4'-oxospiro[2,3-dihydrochromene-4,6'-5,7-dihydropyrazolo[4,3-c]pyridine]-3'-yl]-2-methylsulfonylacetamide;
CAS Number	2267352-04-3;
PubChem CID	153266620;
Chemical and physical data
Formula	C23H21F2N5O5S
Molar mass	517.51 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC1=C2[C@@]3(CC=4C(C(=O)N3)=C(NC(CS(C)(=O)=O)=O)N(N4)C5=CC=C(C)C=N5)CCOC2=CC(F)=C1;
	InChI InChI=1S/C23H21F2N5O5S/c1-12-3-4-17(26-10-12)30-21(27-18(31)11-36(2,33)34)19-15(29-30)9-23(28-22(19)32)5-6-35-16-8-13(24)7-14(25)20(16)23/h3-4,7-8,10H,5-6,9,11H2,1-2H3,(H,27,31)(H,28,32)/t23-/m0/s1; Key:WWHHALBVCASKPG-QHCPKHFHSA-N;

S-309309 is an experimental MGAT2 inhibitor developed as an anti-obesity drug by the Japanese company Shionogi.^[1]^[2] Phase II trial results are expected in late 2023.^[3]

References

^ S-309309: A Novel Selective Inhibitor of MGAT2 That Exert Potent Anti-Obesity Effect in DIO Mice Kato, Hideaki; Takemoto, Kosuke, MS; Higashino, Kenichi. Obesity; Silver Spring Vol. 30, (Nov 2022): 277-278.
^ MGAT2 Inhibition Activates NTS Neurons, Leading to Appetite Suppression and Beneficial Effects Takemoto, Kosuke, MS; Kato, Hideaki; Higashino, Kenichi. Obesity; Silver Spring Vol. 30, (Nov 2022): 278-279.
^ Beaney, Abigail (30 June 2023). "Obesity: Six trials to watch over the next 12 months". Clinical Trials Arena. Retrieved 5 December 2023.

[1] S-309309: A Novel Selective Inhibitor of MGAT2 That Exert Potent Anti-Obesity Effect in DIO Mice Kato, Hideaki; Takemoto, Kosuke, MS; Higashino, Kenichi. Obesity; Silver Spring Vol. 30, (Nov 2022): 277-278.

[2] MGAT2 Inhibition Activates NTS Neurons, Leading to Appetite Suppression and Beneficial Effects Takemoto, Kosuke, MS; Kato, Hideaki; Higashino, Kenichi. Obesity; Silver Spring Vol. 30, (Nov 2022): 278-279.

[3] Beaney, Abigail (30 June 2023). "Obesity: Six trials to watch over the next 12 months". Clinical Trials Arena. Retrieved 5 December 2023.

[1]

[2]

[3]

Legal status

Legal status	Investigational
Identifiers
IUPAC name N-[(4R)-5,7-difluoro-2'-(5-methylpyridin-2-yl)-4'-oxospiro[2,3-dihydrochromene-4,6'-5,7-dihydropyrazolo[4,3-c]pyridine]-3'-yl]-2-methylsulfonylacetamide
CAS Number	2267352-04-3
PubChem CID	153266620
Chemical and physical data
Formula	C₂₃H₂₁F₂N₅O₅S
Molar mass	517.51 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES FC1=C2[C@@]3(CC=4C(C(=O)N3)=C(NC(CS(C)(=O)=O)=O)N(N4)C5=CC=C(C)C=N5)CCOC2=CC(F)=C1
InChI InChI=1S/C23H21F2N5O5S/c1-12-3-4-17(26-10-12)30-21(27-18(31)11-36(2,33)34)19-15(29-30)9-23(28-22(19)32)5-6-35-16-8-13(24)7-14(25)20(16)23/h3-4,7-8,10H,5-6,9,11H2,1-2H3,(H,27,31)(H,28,32)/t23-/m0/s1 Key:WWHHALBVCASKPG-QHCPKHFHSA-N