In enzymology, a S-methyl-5-thioribose-1-phosphate isomerase (EC 5.3.1.23) is an enzyme that catalyzes the chemical reaction
| S-methyl-5-thioribose-1-phosphate isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.3.1.23 | ||||||||
| CAS no. | 91608-95-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- S-methyl-5-thio-alpha-D-ribose 1-phosphate S-methyl-5-thio-D-ribulose 1-phosphate
Hence, this enzyme has one substrate, S-methyl-5-thio-alpha-D-ribose 1-phosphate, and one product, S-methyl-5-thio-D-ribulose 1-phosphate.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase. Other names in common use include methylthioribose 1-phosphate isomerase, 1-PMTR isomerase, 5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase, S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase, S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate, aldose-ketose-isomerase, 1-phospho-5'-S-methylthioribose isomerase, and S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase. This enzyme participates in methionine metabolism.
Structural studies
editAs of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T9K and 1W2W.
References
edit- RH; Savarese, TM; Dexter, DL; Parks Jr, RE; Trackman, PC; Abeles, RH (1984). "Characterization of a defect in the pathway for converting 5'-deoxy-5'-methylthioadenosine to methionine in a subline of a cultured heterogeneous human colon carcinoma". J. Biol. Chem. 259 (11): 6715–9. doi:10.1016/S0021-9258(17)39787-9. PMID 6725268.
- Trackman PC, Abeles RH (1983). "Methionine synthesis from 5'-S-Methylthioadenosine. Resolution of enzyme activities identification of 1-phospho-5-S methylthioribulose". J. Biol. Chem. 258 (11): 6717–20. doi:10.1016/S0021-9258(18)32277-4. PMID 6853500.
- Furfine ES, Abeles RH (1988). "Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae". J. Biol. Chem. 263 (20): 9598–606. doi:10.1016/S0021-9258(19)81558-2. PMID 2838472.
