S3D or S-3D may refer to:
- Stereoscopic 3D, see stereoscopy
- 3D film, films with S-3D
- Stereoscopic video game, video games with S-3D
- S3D, a supercomputer project that models the molecular physics of combustion
- S3D, a diode electrical component
- Rocketdyne S-3D, a rocket engine used in early US ballistic missiles
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