Sin3A-associated protein, 30kDa , also known as SAP30 , is a protein which in humans is encoded by the SAP30 gene .[ 5]
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3A , SAP18 , HDAC1 , HDAC2 , RbAp46 , RbAp48 , and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.[ 5]
Mammals have one paralog of SAP30, named SAP30-like (SAP30L ), which shares 70% sequence identity with SAP30.[ 6] [ 7]
Proteins of the SAP30 family (SAP30 proteins) have a functional nucleolar localization signal and they are able to target Sin3A to the nucleolus.[ 7] [ 8] zinc finger proteins and thus exemplifies the molecular mechanism how these lipids can contribute for gene regulation.[ 8] [ 9]
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