SC-4289

SC-4289
Clinical data
Other names	6-[1'-Ethyl-2',2'-dimethyl-3'-hydroxy]propyl-β-naphthol-2-benzyl ether
Routes of; administration	By mouth
Drug class	Nonsteroidal estrogen
Identifiers
	IUPAC name 2,2-Dimethyl-3-(6'-benzyloxy-2'-naphthyl)pentanol;
PubChem CID	154132848;
Chemical and physical data
Formula	C24H28O2
Molar mass	348.486 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(C1=CC=C2C=C(OCC3=CC=CC=C3)C=CC2=C1)C(C)(C)CO;
	InChI InChI=1S/C24H28O2/c1-4-23(24(2,3)17-25)21-11-10-20-15-22(13-12-19(20)14-21)26-16-18-8-6-5-7-9-18/h5-15,23,25H,4,16-17H2,1-3H3; Key:FRDCVULRLQYMDS-UHFFFAOYSA-N;

SC-4289 is a synthetic nonsteroidal estrogen which, along with mytatrienediol (SC-6924; Manvene, Anvene), was developed in the late 1950s as a potential treatment for atherosclerosis in men but was never marketed.^[2]^[3]

References

^ Berichte über die gesamte Physiologie und experimentelle Pharmakologie. Springer-Verlag. 1958. p. 332,378.
^ ^a ^b Robinson, R. W., Cohen, W. D., & Higano, N. (1956, January). Serum lipid and estrogenic effects of two new „weak estrogens“ in male patients with coronary atherosclerosis. In Circulation (Vol. 14, No. 3, pp. 489-490). 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106: LIPPINCOTT WILLIAMS & WILKINS. http://circ.ahajournals.org/content/circulationaha/14/3/local/back-matter.pdf
^ DAVIS FW, SCARBOROUGH WR, MASON RE, SINGEWALD ML, BAKER BM (1958). "Experimental hormonal therapy of atherosclerosis: preliminary observations on the effects of two new compounds". Am. J. Med. Sci. 235 (1): 50–9. doi:10.1097/00000441-195801000-00006. PMID 13487586. S2CID 762067.

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Clinical data

Other names	6-[1'-Ethyl-2',2'-dimethyl-3'-hydroxy]propyl-β-naphthol-2-benzyl ether^[1]
Routes of administration	By mouth
Drug class	Nonsteroidal estrogen
Identifiers
IUPAC name 2,2-Dimethyl-3-(6'-benzyloxy-2'-naphthyl)pentanol^[2]
PubChem CID	154132848
Chemical and physical data
Formula	C₂₄H₂₈O₂
Molar mass	348.486 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCC(C1=CC=C2C=C(OCC3=CC=CC=C3)C=CC2=C1)C(C)(C)CO
InChI InChI=1S/C24H28O2/c1-4-23(24(2,3)17-25)21-11-10-20-15-22(13-12-19(20)14-21)26-16-18-8-6-5-7-9-18/h5-15,23,25H,4,16-17H2,1-3H3 Key:FRDCVULRLQYMDS-UHFFFAOYSA-N