SC65

Endoplasmic reticulum protein SC65, also known as Leprecan-like protein 4 (LEPREL4) or nucleolar autoantigen No55, is a protein that in humans is encoded by the P3H4 gene.

P3H4
Identifiers
Aliases	P3H4, NO55, NOL55, SC65, LEPREL4, prolyl 3-hydroxylase family member 4 (non-enzymatic), prolyl 3-hydroxylase family member 4 (inactive)
External IDs	OMIM: 617419; MGI: 1913430; HomoloGene: 4713; GeneCards: P3H4; OMA:P3H4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.2 Start 41,801,947 bp End 41,812,604 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 100,299,282 bp End 100,305,662 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium periodontal fiber tibia ventricular zone anterior pituitary right lobe of thyroid gland left adrenal cortex tendon of biceps brachii right adrenal gland body of pancreas Top expressed in calvaria molar epithelium of lens umbilical cord upper jaw body of femur supraoptic nucleus vestibular membrane of cochlear duct ascending aorta right ventricle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 10609 66180 Ensembl ENSG00000141696 ENSMUSG00000006931 UniProt Q92791 Q8K2B0 RefSeq (mRNA) NM_006455 NM_176830 NM_001378981 RefSeq (protein) NP_006446 NP_789800 NP_001365910 Location (UCSC) Chr 17: 41.8 – 41.81 Mb Chr 11: 100.3 – 100.31 Mb PubMed search
Wikidata
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Function

This nucleolar protein was first characterized because it was an autoantigen in cases on interstitial cystitis. The protein, with a predicted molecular weight of 50 kDa, appears to be localized in the particulate compartment of the interphase nucleolus, with a distribution distinct from that of nucleolar protein B23. During mitosis it is associated with chromosomes.

Further reading

• Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fosså A, Siebert R, Aasheim HC, et al. (2000). "Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer". Br. J. Cancer. 83 (6): 743–9. doi:10.1054/bjoc.2000.1365. PMC 2363543. PMID 10952778.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ochs RL, Stein TW, Chan EK, et al. (1996). "cDNA cloning and characterization of a novel nucleolar protein". Mol. Biol. Cell. 7 (7): 1015–24. doi:10.1091/mbc.7.7.1015. PMC 275955. PMID 8862517.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.