SCAMP2

Secretory carrier-associated membrane protein 2 is a protein that in humans is encoded by the SCAMP2 gene.

SCAMP2
Identifiers
Aliases	SCAMP2, secretory carrier membrane protein 2
External IDs	OMIM: 606912; MGI: 1346518; HomoloGene: 4163; GeneCards: SCAMP2; OMA:SCAMP2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q24.1 Start 74,843,730 bp End 74,873,365 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 57,468,226 bp End 57,496,078 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum mucosa of transverse colon granulocyte islet of Langerhans minor salivary glands mucosa of ileum lymph node body of stomach right lung gallbladder Top expressed in spermatid granulocyte stroma of bone marrow corneal stroma epithelium of stomach tibiofemoral joint large intestine colon lip proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane endosome recycling endosome membrane Golgi apparatus trans-Golgi network membrane extracellular exosome transport vesicle intracellular membrane-bounded organelle membrane Golgi membrane Biological process protein transport post-Golgi vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10066 24044 Ensembl ENSG00000140497 ENSMUSG00000040188 UniProt O15127 Q9ERN0 RefSeq (mRNA) NM_005697 NM_001320778 NM_022813 NM_001378928 RefSeq (protein) NP_001307707 NP_005688 NP_073724 NP_001365857 Location (UCSC) Chr 15: 74.84 – 74.87 Mb Chr 9: 57.47 – 57.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways.

Further reading

• Wu TT, Castle JD (1997). "Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs)". J. Cell Sci. 110 (13): 1533–41. doi:10.1242/jcs.110.13.1533. PMID 9224770.
• Guo Z, Liu L, Cafiso D, Castle D (2002). "Perturbation of a very late step of regulated exocytosis by a secretory carrier membrane protein (SCAMP2)-derived peptide". J. Biol. Chem. 277 (38): 35357–63. doi:10.1074/jbc.M202259200. PMID 12124380.
• Liu L, Guo Z, Tieu Q, et al. (2003). "Role of Secretory Carrier Membrane Protein SCAMP2 in Granule Exocytosis". Mol. Biol. Cell. 13 (12): 4266–78. doi:10.1091/mbc.E02-03-0136. PMC 138632. PMID 12475951.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lin PJ, Williams WP, Luu Y, et al. (2005). "Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7". J. Cell Sci. 118 (Pt 9): 1885–97. doi:10.1242/jcs.02315. PMID 15840657.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Müller HK, Wiborg O, Haase J (2006). "Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2". J. Biol. Chem. 281 (39): 28901–9. doi:10.1074/jbc.M602848200. PMID 16870614.
• Liao H, Ellena J, Liu L, et al. (2007). "Secretory carrier membrane protein SCAMP2 and phosphatidylinositol 4,5-bisphosphate interactions in the regulation of dense core vesicle exocytosis". Biochemistry. 46 (38): 10909–20. doi:10.1021/bi701121j. PMID 17713930.

External links

• SCAMP2 human gene location in the UCSC Genome Browser.
• SCAMP2 human gene details in the UCSC Genome Browser.