(S)-SCQ1 is a drug which acts as a potent and selective antagonist for the 5-HT2B and 5-HT2C serotonin receptors, but with only modest affinity for the closely related 5-HT2A receptor and other targets such as 5-HT7. Since most currently available 5-HT2 class ligands have relatively poor selectivity and bind to all three subtypes, the selectivity of (S)-SCQ1 is expected to be useful for studying 5-HT2A receptor mediated responses in the absence of 5-HT2B and 5-HT2C activation.[1]
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| Chemical and physical data | |
| Formula | C19H19NO2 |
| Molar mass | 293.366 g·mol−1 |
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See also
editReferences
edit- ^ Yao R, Jensen AA, Bryce-Rogers HP, Schultz-Knudsen K, Zhou L, Hovendal NP, et al. (August 2023). "Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library". Journal of Medicinal Chemistry. 66 (16): 11536–11554. doi:10.1021/acs.jmedchem.3c01059. PMID 37566000. S2CID 260806387.