SDK1

Sidekick cell adhesion molecule 1 is a protein that in humans is encoded by the SDK1 gene.

SDK1
Identifiers
Aliases	SDK1, sidekick cell adhesion molecule 1
External IDs	OMIM: 607216; MGI: 2444413; HomoloGene: 27395; GeneCards: SDK1; OMA:SDK1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p22.2 Start 3,301,252 bp End 4,269,000 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 141,227,245 bp End 142,201,341 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery decidua tibial arteries body of pancreas sural nerve islet of Langerhans olfactory zone of nasal mucosa gonad Descending thoracic aorta ascending aorta Top expressed in otolith organ utricle Jacobson's organ gastrula internal carotid artery genital tubercle lens external carotid artery zygote sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function identical protein binding Cellular component integral component of membrane cell junction synapse membrane plasma membrane Biological process synapse assembly cell adhesion retina layer formation regulation of dendritic spine development behavioral response to cocaine homophilic cell adhesion via plasma membrane adhesion molecules cell-cell junction organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221935 330222 Ensembl ENSG00000146555 ENSMUSG00000039683 UniProt Q7Z5N4 Q3UH53 RefSeq (mRNA) NM_001079653 NM_152744 NM_177879 RefSeq (protein) NP_001073121 NP_689957 NP_808547 Location (UCSC) Chr 7: 3.3 – 4.27 Mb Chr 5: 141.23 – 142.2 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].

Further reading

• Yamagata M (2020). "Structure and Functions of Sidekicks". Frontiers in Molecular Neuroscience. 13: 139. doi:10.3389/fnmol.2020.00139. PMC 7479261. PMID 32982686.
• Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE (July 2004). "Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy". J. Am. Soc. Nephrol. 15 (7): 1721–30. doi:10.1097/01.asn.0000128975.28958.c2. PMID 15213259.
• Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (January 2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
• Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (January 2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
• Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (April 2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi:10.3892/ijmm_00000388. PMID 20198315.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X (October 2010). "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients". J Psychiatr Res. 44 (14): 971–8. doi:10.1016/j.jpsychires.2010.03.007. PMID 20398908.
• Kaufman L, Potla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D'Agati VD, Klotman PE (August 2010). "Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis". J. Biol. Chem. 285 (33): 25677–85. doi:10.1074/jbc.M110.133959. PMC 2919131. PMID 20562105.
• Cadby G, Mukherjee S, Musk AW, Reid A, Garlepp M, Dick I, Robinson C, Hui J, Fiorito G, Guarrera S, Beilby J, Melton PE, Moses EK, Ugolini D, Mirabelli D, Bonassi S, Magnani C, Dianzani I, Matullo G, Robinson B, Creaney J, Palmer LJ (October 2013). "A genome-wide association study for malignant mesothelioma risk". Lung Cancer. 82 (1): 1–8. doi:10.1016/j.lungcan.2013.04.018. hdl:11567/604944. PMID 23827383.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.