Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene.[5][6][7]

SEC61G
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEC61G, SSS1, Sec61 translocon gamma subunit, SEC61 translocon subunit gamma
External IDsOMIM: 609215; MGI: 1202066; HomoloGene: 40767; GeneCards: SEC61G; OMA:SEC61G - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014302
NM_001012456

NM_001109971
NM_001109972
NM_011343

RefSeq (protein)

NP_001012474
NP_055117

NP_001103441
NP_001103442
NP_035473

Location (UCSC)Chr 7: 54.75 – 54.76 MbChr 11: 16.5 – 16.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified.[7]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132432Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078974Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA (February 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. Bibcode:1994Natur.367..654H. doi:10.1038/367654a0. PMID 8107851. S2CID 4323463.
  6. ^ Greenfield JJ, High S (May 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". Journal of Cell Science. 112 ( Pt 10) (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID 10212142.
  7. ^ a b "Entrez Gene: SEC61G Sec61 gamma subunit".

Further reading

edit