SECTM1

Secreted and transmembrane protein 1 is a protein that in humans is encoded by the SECTM1 gene.

SECTM1
Identifiers
Aliases	SECTM1, K12, secreted and transmembrane 1, SECTM
External IDs	OMIM: 602602; MGI: 2384805; HomoloGene: 134112; GeneCards: SECTM1; OMA:SECTM1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 82,321,024 bp End 82,334,074 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 120,958,233 bp End 120,972,046 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood mucosa of transverse colon mucosa of ileum jejunal mucosa duodenum spleen appendix decidua Top expressed in skin of external ear epithelium of stomach epithelium of small intestine seminal vesicula mucous cell of stomach lip right kidney duodenum jejunum spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity cytokine activity Cellular component extracellular region Golgi apparatus plasma membrane membrane extracellular exosome integral component of membrane extracellular space Biological process mesoderm development positive regulation of I-kappaB kinase/NF-kappaB signaling immune response signal transduction regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6398 209588 Ensembl ENSG00000141574 ENSMUSG00000025165 UniProt Q8WVN6 Q921W8 RefSeq (mRNA) NM_003004 NM_145373 RefSeq (protein) NP_002995 n/a Location (UCSC) Chr 17: 82.32 – 82.33 Mb Chr 11: 120.96 – 120.97 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lyman SD, Escobar S, Rousseau AM, et al. (2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein". J. Biol. Chem. 275 (5): 3431–7. doi:10.1074/jbc.275.5.3431. PMID 10652336.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.