SEPT3

Neuronal-specific septin-3 is a protein that in humans is encoded by the SEPT3 gene.

SEPTIN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SOP, 4Z51, 4Z54
Identifiers
Aliases	SEPTIN3, SEP3, bK250D10.3, septin 3, SEPT3
External IDs	OMIM: 608314; MGI: 1345148; HomoloGene: 99740; GeneCards: SEPTIN3; OMA:SEPTIN3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.2 Start 41,969,475 bp End 41,998,221 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 82,153,003 bp End 82,178,775 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right frontal lobe ventricular zone dorsolateral prefrontal cortex cingulate gyrus anterior cingulate cortex prefrontal cortex Brodmann area 9 cerebellar hemisphere amygdala Top expressed in dentate gyrus of hippocampal formation granule cell cerebellar vermis superior frontal gyrus lobe of cerebellum primary visual cortex subiculum piriform cortex cingulate gyrus primary motor cortex hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding identical protein binding molecular function GTPase activity molecular adaptor activity Cellular component cytoplasm cell junction synapse cytoskeleton septin ring microtubule cytoskeleton septin complex septin filament array neuron projection presynaptic cytoskeleton presynapse Biological process cell cycle cell division mitotic cytokinesis septin ring assembly cilium assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55964 24050 Ensembl ENSG00000100167 ENSMUSG00000022456 UniProt Q9UH03 Q9Z1S5 RefSeq (mRNA) NM_145734 NM_019106 NM_145733 NM_001363845 NM_011889 NM_001358836 NM_001358837 NM_001368642 NM_001368643 NM_001368644 NM_001368645 NM_001368646 NM_001368647 NM_001368784 NM_001368785 RefSeq (protein) NP_061979 NP_663786 NP_001350774 NP_036019 NP_001345765 NP_001345766 Location (UCSC) Chr 22: 41.97 – 42 Mb Chr 15: 82.15 – 82.18 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in multiple transcript variants.

Further reading

• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Methner A, Leypoldt F, Joost P, Lewerenz J (April 2001). "Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation". Biochemical and Biophysical Research Communications. 283 (1): 48–56. doi:10.1006/bbrc.2001.4741. PMID 11322766.
• Xue J, Milburn PJ, Hanna BT, Graham ME, Rostas JA, Robinson PJ (August 2004). "Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals". The Biochemical Journal. 381 (Pt 3): 753–60. doi:10.1042/BJ20040455. PMC 1133885. PMID 15107017.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Xue J, Tsang CW, Gai WP, Malladi CS, Trimble WS, Rostas JA, Robinson PJ (November 2004). "Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals". Journal of Neurochemistry. 91 (3): 579–90. doi:10.1111/j.1471-4159.2004.02755.x. PMID 15485489. S2CID 2730644.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.