SEPT4

Septin-4 is a protein that in humans is encoded by the SEPT4 gene.

SEPT4
Identifiers
Aliases	SEPT4, ARTS, BRADEION, CE5B3, H5, MART, PNUTL2, SEP4, hCDCREL-2, hucep-7, septin 4, Sept4
External IDs	OMIM: 603696; MGI: 1270156; HomoloGene: 6107; GeneCards: SEPT4; OMA:SEPT4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q22 Start 58,520,250 bp End 58,540,818 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 C Start 87,457,479 bp End 87,481,365 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment right hemisphere of cerebellum middle frontal gyrus paraflocculus of cerebellum corpus callosum external globus pallidus right frontal lobe internal globus pallidus putamen inferior ganglion of vagus nerve Top expressed in lobe of cerebellum cerebellar vermis deep cerebellar nuclei lateral geniculate nucleus globus pallidus anterior horn of spinal cord neural layer of retina central gray substance of midbrain superior colliculus nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding structural molecule activity protein binding magnesium ion binding GTPase activity GTP binding protein homodimerization activity molecular adaptor activity Cellular component cytoplasm cell projection myelin sheath sperm flagellum nucleoplasm mitochondrion motile cilium cytoskeleton nucleus sperm annulus septin complex cilium septin ring synaptic vesicle microtubule cytoskeleton septin filament array mitochondrial outer membrane cytosol Biological process regulation of apoptotic process sperm mitochondrion organization cell division brain development spermatid development positive regulation of apoptotic process sperm capacitation cell cycle positive regulation of protein ubiquitination positive regulation of intrinsic apoptotic signaling pathway apoptotic process spermatogenesis cell differentiation protein homooligomerization mitotic cytokinesis septin ring assembly regulation of exocytosis cilium assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5414 18952 Ensembl ENSG00000108387 ENSMUSG00000020486 UniProt O43236 P28661 RefSeq (mRNA) NM_001198713 NM_001256782 NM_001256822 NM_004574 NM_080415 NM_080416 NM_080417 NM_001284392 NM_001284394 NM_001284398 NM_011129 NM_001361936 NM_001368775 NM_001368776 NM_001368777 NM_001368778 NM_001368779 RefSeq (protein) NP_001185642 NP_001243711 NP_001243751 NP_004565 NP_536340 NP_536341 NP_001350732 NP_001033793 NP_001355700 NP_001355701 NP_001271321 NP_001271323 NP_001271327 NP_035259 NP_001348865 NP_001355704 NP_001355705 NP_001355706 NP_001355707 NP_001355708 Location (UCSC) Chr 17: 58.52 – 58.54 Mb Chr 11: 87.46 – 87.48 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. The protein encoded by this gene is thought to be part of a complex involved in cytokinesis. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Further reading

• Xie H, Surka M, Howard J, Trimble WS (1999). "Characterization of the mammalian septin H5: distinct patterns of cytoskeletal and membrane association from other septin proteins". Cell Motility and the Cytoskeleton. 43 (1): 52–62. doi:10.1002/(SICI)1097-0169(1999)43:1<52::AID-CM6>3.0.CO;2-5. PMID 10340703.
• Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, Gottfried Y, Birkey Reffey S, de Caestecker MP, Danielpour D, Book-Melamed N, Timberg R, Duckett CS, Lechleider RJ, Steller H, Orly J, Kim SJ, Roberts AB (December 2000). "A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif". Nature Cell Biology. 2 (12): 915–21. doi:10.1038/35046566. PMID 11146656. S2CID 12321788.
• Zieger B, Tran H, Hainmann I, Wunderle D, Zgaga-Griesz A, Blaser S, Ware J (December 2000). "Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2". Gene. 261 (2): 197–203. doi:10.1016/S0378-1119(00)00527-8. PMID 11167005.
• Tanaka M, Tanaka T, Kijima H, Itoh J, Matsuda T, Hori S, Yamamoto M (August 2001). "Characterization of tissue- and cell-type-specific expression of a novel human septin family gene, Bradeion". Biochemical and Biophysical Research Communications. 286 (3): 547–53. doi:10.1006/bbrc.2001.5413. PMID 11511094.
• Tanaka M, Kijima H, Itoh J, Matsuda T, Tanaka T (June 2002). "Impaired expression of a human septin family gene Bradeion inhibits the growth and tumorigenesis of colorectal cancer in vitro and in vivo". Cancer Gene Therapy. 9 (6): 483–8. doi:10.1038/sj.cgt.7700460. PMID 12032658.
• Vega IE, Hsu SC (January 2003). "The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells". NeuroReport. 14 (1): 31–7. doi:10.1097/00001756-200301200-00006. PMID 12544826. S2CID 22757290.
• Ihara M, Tomimoto H, Kitayama H, Morioka Y, Akiguchi I, Shibasaki H, Noda M, Kinoshita M (June 2003). "Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies". The Journal of Biological Chemistry. 278 (26): 24095–102. doi:10.1074/jbc.M301352200. PMID 12695511.
• Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B (October 2003). "SEPT5_v2 is a parkin-binding protein". Brain Research. Molecular Brain Research. 117 (2): 179–89. doi:10.1016/S0169-328X(03)00318-8. PMID 14559152.
• Gottfried Y, Rotem A, Lotan R, Steller H, Larisch S (April 2004). "The mitochondrial ARTS protein promotes apoptosis through targeting XIAP". The EMBO Journal. 23 (7): 1627–35. doi:10.1038/sj.emboj.7600155. PMC 391065. PMID 15029247.
• Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B (May 2004). "The novel human platelet septin SEPT8 is an interaction partner of SEPT4". Thrombosis and Haemostasis. 91 (5): 959–66. doi:10.1160/TH03-09-0578. PMID 15116257. S2CID 22853459.
• Elhasid R, Sahar D, Merling A, Zivony Y, Rotem A, Ben-Arush M, Izraeli S, Bercovich D, Larisch S (July 2004). "Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients". Oncogene. 23 (32): 5468–75. doi:10.1038/sj.onc.1207725. PMID 15122323.
• Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J (September 2004). "Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol". The Biochemical Journal. 382 (Pt 3): 783–91. doi:10.1042/BJ20040372. PMC 1133953. PMID 15214843.
• Lotan R, Rotem A, Gonen H, Finberg JP, Kemeny S, Steller H, Ciechanover A, Larisch S (July 2005). "Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation". The Journal of Biological Chemistry. 280 (27): 25802–10. doi:10.1074/jbc.M501955200. PMID 15837787.
• Lee JW, Soung YH, Young Kim S, Woo Nam S, Sang Park W, Young Lee J, Jin Yoo N, Lee SH (2006). "Mutational analysis of proapoptotic ARTS P-loop domain in common human cancers". Pathology, Research and Practice. 202 (2): 67–70. doi:10.1016/j.prp.2005.11.001. PMID 16376484.
• Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH (2006). "Mutational analysis of P-loop domains of proapoptotic Nod1 and ARTS genes in colon carcinomas". Acta Oncologica. 45 (1): 101–2. doi:10.1080/02841860500374497. PMID 16464805. S2CID 218896700.
• Garcia W, de Araújo AP, Neto Mde O, Ballestero MR, Polikarpov I, Tanaka M, Tanaka T, Garratt RC (November 2006). "Dissection of a human septin: definition and characterization of distinct domains within human SEPT4". Biochemistry. 45 (46): 13918–31. doi:10.1021/bi061549z. PMID 17105210.