SFRS6

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.

SRSF6
Identifiers
Aliases	SRSF6, B52, HEL-S-91, SFRS6, SRP55, serine/arginine-rich splicing factor 6, serine and arginine rich splicing factor 6
External IDs	OMIM: 601944; MGI: 1915246; HomoloGene: 110783; GeneCards: SRSF6; OMA:SRSF6 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.11 Start 43,457,893 bp End 43,466,046 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H2|2 83.87 cM Start 162,773,448 bp End 162,779,041 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube body of pancreas right lobe of thyroid gland right adrenal cortex right ovary left lobe of thyroid gland left ovary germinal epithelium ventricular zone left adrenal gland Top expressed in medullary collecting duct abdominal wall renal corpuscle endocardial cushion somite superior cervical ganglion epiblast ventricular zone dermis Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding nucleic acid binding pre-mRNA binding Cellular component nuclear speck nucleus nucleoplasm Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription negative regulation of keratinocyte differentiation positive regulation of epithelial cell proliferation involved in lung morphogenesis mRNA processing negative regulation of cell death regulation of alternative mRNA splicing, via spliceosome mRNA export from nucleus negative regulation of mRNA splicing, via spliceosome regulation of wound healing mRNA splice site selection regulation of keratinocyte proliferation alternative mRNA splicing, via spliceosome mRNA 3'-end processing negative regulation of gene expression RNA splicing response to insulin RNA export from nucleus negative regulation of type B pancreatic cell apoptotic process mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6431 67996 Ensembl ENSG00000124193 ENSMUSG00000016921 UniProt Q13247 Q3TWW8 RefSeq (mRNA) NM_006275 NM_026499 RefSeq (protein) NP_006266 NP_080775 Location (UCSC) Chr 20: 43.46 – 43.47 Mb Chr 2: 162.77 – 162.78 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.

Further reading

• Zahler AM, Lane WS, Stolk JA, Roth MB (May 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes & Development. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
• Ramchatesingh J, Zahler AM, Neugebauer KM, Roth MB, Cooper TA (September 1995). "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer". Molecular and Cellular Biology. 15 (9): 4898–907. doi:10.1128/MCB.15.9.4898. PMC 230736. PMID 7651409.
• Gui JF, Lane WS, Fu XD (June 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-11.
• Nagel RJ, Lancaster AM, Zahler AM (January 1998). "Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55". RNA. 4 (1): 11–23. PMC 1369592. PMID 9436904.
• Liu HX, Zhang M, Krainer AR (July 1998). "Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins". Genes & Development. 12 (13): 1998–2012. doi:10.1101/gad.12.13.1998. PMC 316967. PMID 9649504.
• Lemaire R, Winne A, Sarkissian M, Lafyatis R (March 1999). "SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation". European Journal of Immunology. 29 (3): 823–37. doi:10.1002/(SICI)1521-4141(199903)29:03<823::AID-IMMU823>3.0.CO;2-C. PMID 10092085. S2CID 23297953.
• Paillard F (May 1999). "A novel soluble chimera for the treatment of familial hypercholesterolemia". Human Gene Therapy. 10 (7): 1093–4. doi:10.1089/10430349950018085. PMID 10340541.
• Barnard DC, Patton JG (May 2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Molecular and Cellular Biology. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.
• Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM (August 2000). "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1". Molecular Cell. 6 (2): 307–16. doi:10.1016/S1097-2765(00)00031-9. PMID 10983978.
• Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW (August 2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
• Tran Q, Coleman TP, Roesser JR (January 2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1625 (2): 141–52. doi:10.1016/S0167-4781(02)00600-0. PMID 12531473.
• Tran Q, Roesser JR (February 2003). "SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing". Biochemistry. 42 (4): 951–7. doi:10.1021/bi026753a. PMID 12549914.
• Lai MC, Lin RI, Tarn WY (May 2003). "Differential effects of hyperphosphorylation on splicing factor SRp55". The Biochemical Journal. 371 (Pt 3): 937–45. doi:10.1042/BJ20021827. PMC 1223332. PMID 12549978.
• Pind MT, Watson PH (May 2003). "SR protein expression and CD44 splicing pattern in human breast tumours". Breast Cancer Research and Treatment. 79 (1): 75–82. doi:10.1023/A:1023338718974. PMID 12779084. S2CID 24657578.
• Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (November 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.