SH2D2A

SH2 domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene.

SH2D2A
Identifiers
Aliases	SH2D2A, F2771, SCAP, TSAD, VRAP, SH2 domain containing 2A
External IDs	OMIM: 604514; MGI: 1351596; HomoloGene: 2958; GeneCards: SH2D2A; OMA:SH2D2A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.1 Start 156,806,243 bp End 156,816,848 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F1|3 38.78 cM Start 87,754,062 bp End 87,763,029 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte testicle blood gonad spleen appendix epithelium of colon lymph node apex of heart upper lobe of left lung Top expressed in thymus blood embryo mesenteric lymph nodes spleen subcutaneous adipose tissue hematopoietic cell granulocyte jejunum islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding protein binding Cellular component cytoplasm cytosol Biological process multicellular organism development cell differentiation vascular endothelial growth factor receptor signaling pathway cell population proliferation angiogenesis signal transduction positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9047 27371 Ensembl ENSG00000027869 ENSMUSG00000028071 UniProt Q9NP31 Q9QXK9 RefSeq (mRNA) NM_001161441 NM_001161442 NM_001161443 NM_001161444 NM_003975 NM_001025571 NM_021309 RefSeq (protein) NP_001154913 NP_001154914 NP_001154915 NP_001154916 NP_003966 NP_001020742 NP_067284 Location (UCSC) Chr 1: 156.81 – 156.82 Mb Chr 3: 87.75 – 87.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SH2D2A has been shown to interact with MAP3K2.

Further reading

• Marti F, Lapinski PE, King PD (March 2005). "The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man". Immunology Letters. 97 (2): 165–70. doi:10.1016/j.imlet.2004.10.019. PMID 15752554.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Choi YB, Kim CK, Yun Y (November 1999). "Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation". Journal of Immunology. 163 (10): 5242–9. doi:10.4049/jimmunol.163.10.5242. PMID 10553045. S2CID 12378851.
• Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, Sperling AI, Kozak CA, Love PE, Bluestone JA (December 1999). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation". The Journal of Experimental Medicine. 190 (11): 1657–68. doi:10.1084/jem.190.11.1657. PMC 2195727. PMID 10587356.
• Wu LW, Mayo LD, Dunbar JD, Kessler KM, Ozes ON, Warren RS, Donner DB (March 2000). "VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor". The Journal of Biological Chemistry. 275 (9): 6059–62. doi:10.1074/jbc.275.9.6059. PMID 10692392.
• Dai KZ, Vergnaud G, Ando A, Inoko H, Spurkland A (March 2000). "The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1". Immunogenetics. 51 (3): 179–85. doi:10.1007/s002510050029. PMID 10752626. S2CID 37269923.
• Smerdel A, Dai KZ, Lorentzen AR, Flatø B, Maslinski S, Thorsby E, Førre Ø, Spurkland A (June 2004). "Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene". Genes and Immunity. 5 (4): 310–2. doi:10.1038/sj.gene.6364093. PMID 15129233. S2CID 23995329.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Matsumoto T, Bohman S, Dixelius J, Berge T, Dimberg A, Magnusson P, Wang L, Wikner C, Qi JH, Wernstedt C, Wu J, Bruheim S, Mugishima H, Mukhopadhyay D, Spurkland A, Claesson-Welsh L (July 2005). "VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis". The EMBO Journal. 24 (13): 2342–53. doi:10.1038/sj.emboj.7600709. PMC 1173150. PMID 15962004.
• Park D, Park I, Lee D, Choi YB, Lee H, Yun Y (June 2007). "The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration". Blood. 109 (12): 5122–8. doi:10.1182/blood-2005-10-061838. PMID 17327418.