SH3GLB2

SH3GLB2
Identifiers
Aliases	SH3GLB2, PP6569, PP9455, RRIG1, SH3 domain containing GRB2 like endophilin B2, SH3 domain containing GRB2 like, endophilin B2
External IDs	OMIM: 609288; MGI: 2385131; HomoloGene: 10595; GeneCards: SH3GLB2; OMA:SH3GLB2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	129,028,331 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	30,249,349 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; C1 segment; ; right frontal lobe; ; skin of abdomen; ; skin of leg; ; anterior cingulate cortex; ; right hemisphere of cerebellum; ; prefrontal cortex; ; body of stomach; ; right uterine tube;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; interventricular septum; ; transitional epithelium of urinary bladder; ; lip; ; neural layer of retina; ; central gray substance of midbrain; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding; cadherin binding;
Cellular component	cytoplasm; nucleoplasm; cytosol;
Biological process	cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	56904
	227700
	ENSG00000148341
	ENSMUSG00000026860
	Q9NR46
	Q8R3V5
NM_001287045; NM_001287046; NM_020145; NM_001369913; NM_001369914;
	NM_001369915
	NM_001289709; NM_001289710; NM_139302; NM_001346806; NM_001362888
NP_001273974; NP_001273975; NP_064530; NP_001356842; NP_001356843;
	NP_001356844
	NP_001276638; NP_001276639; NP_001333735; NP_647463; NP_001349817
	Wikidata
View/Edit Human	View/Edit Mouse

Endophilin-B2 is a protein that in humans is encoded by the SH3GLB2 gene.^[5]^[6]

Interactions

SH3GLB2 has been shown to interact with SH3GLB1^[5] and SH3KBP1.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148341 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026860 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (February 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–34. doi:10.1006/geno.2000.6378. PMID 11161816.
^ "Entrez Gene: SH3GLB2 SH3-domain GRB2-like endophilin B2".
^ Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. Bibcode:2002Natur.416..187P. doi:10.1038/416187a. PMID 11894096. S2CID 4389099.
^ Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. PMID 11894095. S2CID 635702.

Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mikula M, Dzwonek A, Karczmarski J, Rubel T, Dadlez M, Wyrwicz LS, Bomsztyk K, Ostrowski J (2006). "Landscape of the hnRNP K protein-protein interactome". Proteomics. 6 (8): 2395–406. doi:10.1002/pmic.200500632. PMID 16518874. S2CID 24395284.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148341 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026860 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11161816-5] Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (February 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–34. doi:10.1006/geno.2000.6378. PMID 11161816.

[entrez-6] "Entrez Gene: SH3GLB2 SH3-domain GRB2-like endophilin B2".

[pmid11894096-7] Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. Bibcode:2002Natur.416..187P. doi:10.1038/416187a. PMID 11894096. S2CID 4389099.

[pmid11894095-8] Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. PMID 11894095. S2CID 635702.

[5]

[6]

[1]

[2]

[3]

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[7]

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SH3GLB2

Interactions

References

Further reading