SHCBP1

SHC SH2 domain-binding protein 1 is a protein that in humans is encoded by the SHCBP1 gene.

SHCBP1
Identifiers
Aliases	SHCBP1, PAL, SHC binding and spindle associated 1
External IDs	OMIM: 611027; MGI: 1338802; HomoloGene: 32123; GeneCards: SHCBP1; OMA:SHCBP1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q11.2 Start 46,578,591 bp End 46,621,379 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A1.1 Start 4,785,976 bp End 4,829,567 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone bone marrow gonad ganglionic eminence trabecular bone stromal cell of endometrium bone marrow cells appendix testicle Top expressed in otic placode otic vesicle saccule primitive streak maxillary prominence mandibular prominence abdominal wall condyle vas deferens dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH2 domain binding protein binding Cellular component cytoskeleton cytoplasm spindle midbody Biological process regulation of neural precursor cell proliferation fibroblast growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79801 20419 Ensembl ENSG00000171241 ENSMUSG00000022322 UniProt Q8NEM2 Q9Z179 RefSeq (mRNA) NM_024745 NM_001324318 NM_001324319 NM_011369 RefSeq (protein) NP_001311247 NP_001311248 NP_079021 NP_035499 Location (UCSC) Chr 16: 46.58 – 46.62 Mb Chr 8: 4.79 – 4.83 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SHCBP1 has been shown to interact with SHC1.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–120. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–1450. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.