SL2 RNA is a non-coding RNA involved in trans splicing in lower eukaryotes. Trans-splicing is a form of RNA processing. The acquisition of a spliced leader from an SL RNA is an inter-molecular reaction which precisely joins exons derived from separately transcribed RNAs.[1] Approximately 25% of C. elegans genes are organised into polycistronic transcription units and the presence of SL2 on an mRNA is an indication the gene is in an operon.[2]
| SL2 RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of SL2 | |
| Identifiers | |
| Symbol | SL2 |
| Rfam | RF00199 |
| Other data | |
| RNA type | Gene |
| Domain(s) | Eukaryota |
| GO | GO:0000365 |
| SO | SO:0000233 |
| PDB structures | PDBe |
References
edit- ^ Dassanayake RS, Chandrasekharan NV, Karunanayake EH (May 2001). "Trans-spliced leader RNA, 5S-rRNA genes and novel variant orphan spliced-leader of the lymphatic filarial nematode Wuchereria bancrofti, and a sensitive polymerase chain reaction based detection assay". Gene. 269 (1–2): 185–193. doi:10.1016/S0378-1119(01)00438-3. PMID 11376950.
- ^ Evans D, Blumenthal T (September 2000). "trans splicing of polycistronic Caenorhabditis elegans pre-mRNAs: analysis of the SL2 RNA". Molecular and Cellular Biology. 20 (18): 6659–6667. doi:10.1128/MCB.20.18.6659-6667.2000. PMC 86170. PMID 10958663.
External links
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