SLC17A3

Solute carrier family 17 (organic anion transporter), member 3 is a protein that in humans is encoded by the SLC17A3 gene.

SLC17A3
Identifiers
Aliases	SLC17A3, NPT4, GOUT4, UAQTL4, solute carrier family 17 member 3
External IDs	OMIM: 611034; MGI: 2389216; HomoloGene: 21319; GeneCards: SLC17A3; OMA:SLC17A3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.2 Start 25,833,066 bp End 25,882,286 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.1 Start 24,023,417 bp End 24,044,699 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule right lobe of liver glomerulus metanephric glomerulus human kidney testicle renal medulla right adrenal gland left adrenal gland right adrenal cortex Top expressed in right kidney human kidney proximal tubule left lobe of liver outer renal medulla outer stripe of outer renal medulla glomerulus distal tubule proximal straight tubule proximal convoluted tubule More reference expression data BioGPS n/a
Gene ontology Molecular function efflux transmembrane transporter activity voltage-gated anion channel activity xenobiotic transmembrane transporter activity toxin transmembrane transporter activity symporter activity organic anion transmembrane transporter activity sodium:phosphate symporter activity urate transmembrane transporter activity sialic acid transmembrane transporter activity Cellular component brush border membrane integral component of membrane perinuclear region of cytoplasm membrane endoplasmic reticulum integral component of plasma membrane plasma membrane cytoplasm endoplasmic reticulum membrane apical plasma membrane lysosome Biological process sodium ion transport sodium ion transmembrane transport ion transmembrane transport glucose-6-phosphate transport organic anion transport urate metabolic process phosphate ion transport urate transport ion transport toxin transport xenobiotic transmembrane transport transmembrane transport sialic acid transport xenobiotic detoxification by transmembrane export across the plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10786 105355 Ensembl ENSG00000124564 ENSMUSG00000036083 UniProt O00476 n/a RefSeq (mRNA) NM_006632 NM_001098486 NM_001164743 NM_134069 RefSeq (protein) NP_001091956 NP_006623 n/a Location (UCSC) Chr 6: 25.83 – 25.88 Mb Chr 13: 24.02 – 24.04 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum.

See also

• Glycogen storage disease type I

Further reading

• Polasek O, Jeroncić I, Mulić R, Klismanic Z, Pehlić M, Zemunik T, Kolcić I (2010). "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series". Croat. Med. J. 51 (1): 32–9. doi:10.3325/cmj.2010.51.32. PMC 2829186. PMID 20162743.
• Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS (2008). "Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study". Lancet. 372 (9654): 1953–61. doi:10.1016/S0140-6736(08)61343-4. PMC 2803340. PMID 18834626.
• Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Res. 7 (5): 441–56. doi:10.1101/gr.7.5.441. PMID 9149941.
• Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H (2010). "Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate". J. Biol. Chem. 285 (45): 35123–32. doi:10.1074/jbc.M110.121301. PMC 2966126. PMID 20810651.
• Stark K, Reinhard W, Grassl M, Erdmann J, Schunkert H, Illig T, Hengstenberg C (2009). "Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease". PLOS ONE. 4 (11): e7729. Bibcode:2009PLoSO...4.7729S. doi:10.1371/journal.pone.0007729. PMC 2766838. PMID 19890391.
• Jutabha P, Anzai N, Kimura T, Taniguchi A, Urano W, Yamanaka H, Endou H, Sakurai H (2011). "Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms". J. Pharmacol. Sci. 115 (2): 249–53. doi:10.1254/jphs.10228sc. PMID 21282933.
• Melis D, Havelaar AC, Verbeek E, Smit GP, Benedetti A, Mancini GM, Verheijen F (2004). "NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic". J. Inherit. Metab. Dis. 27 (6): 725–33. doi:10.1023/B:BOLI.0000045755.89308.2f. PMID 15505377. S2CID 20942710.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.