Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.[5][6]

SLC22A4
Identifiers
AliasesSLC22A4, OCTN1, solute carrier family 22 member 4, DFNB60
External IDsOMIM: 604190; MGI: 1353479; HomoloGene: 81701; GeneCards: SLC22A4; OMA:SLC22A4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003059

NM_019687
NM_001330304

RefSeq (protein)

NP_003050

NP_001317233
NP_062661

Location (UCSC)Chr 5: 132.29 – 132.34 MbChr 11: 53.87 – 53.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), but efficiency of transport for organic cations (e.g., tetraethylammonium) is very low. The transport efficiency for carnitine is also negligible. Instead, the protein is responsible for the cotransport of sodium ions and ergothioneine, which is an antioxidant, into cells.[7] Thus, a more appropriate functional designation is ETT ("ergothioneine transporter").[5]

Interactions

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SLC22A4 has been shown to interact with PDZK1.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197208Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020334Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Gründemann, Dirk; Hartmann, Lea; Flögel, Svenja (May 2022). "The ergothioneine transporter (ETT): substrates and locations, an inventory". FEBS Letters. 596 (10): 1252–1269. doi:10.1002/1873-3468.14269. PMID 34958679. S2CID 245535600.
  6. ^ "Entrez Gene: SLC22A4 solute carrier family 22 (ergothioneine transporter), member 4".
  7. ^ Gründemann D, Harlfinger S, Golz S, Geerts A, Lazar A, Berkels R, Jung N, Rubbert A, Schömig E (Apr 2005). "Discovery of the ergothioneine transporter". Proceedings of the National Academy of Sciences of the United States of America. 102 (14): 5256–61. Bibcode:2005PNAS..102.5256G. doi:10.1073/pnas.0408624102. PMC 555966. PMID 15795384.
  8. ^ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.