Sodium bicarbonate cotransporter 3

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.

SLC4A7
Identifiers
Aliases	SLC4A7, NBC2, NBC3, NBCN1, SBC2, SLC4A6, solute carrier family 4 member 7
External IDs	OMIM: 603353; MGI: 2443878; HomoloGene: 2680; GeneCards: SLC4A7; OMA:SLC4A7 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p24.1 Start 27,372,721 bp End 27,484,420 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 A1 Start 14,702,279 bp End 14,799,940 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte duodenum Achilles tendon jejunal mucosa secondary oocyte lactiferous duct sural nerve frontal pole paraflocculus of cerebellum Brodmann area 23 Top expressed in duodenum left colon retina olfactory epithelium neural layer of retina medial ganglionic eminence islet of Langerhans uterus soleus muscle spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inorganic anion exchanger activity symporter activity anion transmembrane transporter activity sodium:bicarbonate symporter activity protein binding Cellular component integral component of membrane cell projection membrane plasma membrane synapse stereocilium basolateral plasma membrane apical plasma membrane cytoplasmic vesicle integral component of plasma membrane Biological process sodium ion transport anion transport auditory receptor cell development ion transport inorganic anion transport regulation of intracellular pH bicarbonate transport transmembrane transport anion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9497 218756 Ensembl ENSG00000033867 ENSMUSG00000021733 UniProt Q9Y6M7 Q8BTY2 RefSeq (mRNA) NM_001258379 NM_001258380 NM_003615 NM_001321103 NM_001321104 NM_001321105 NM_001321106 NM_001321107 NM_001321108 NM_001033270 RefSeq (protein) NP_001245308 NP_001245309 NP_001308032 NP_001308033 NP_001308034 NP_001308035 NP_001308036 NP_001308037 NP_003606 n/a Location (UCSC) Chr 3: 27.37 – 27.48 Mb Chr 14: 14.7 – 14.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

Further reading

• Ishibashi K, Sasaki S, Marumo F (1998). "Molecular cloning of a new sodium bicarbonate cotransporter cDNA from human retina". Biochem. Biophys. Res. Commun. 246 (2): 535–8. doi:10.1006/bbrc.1998.8658. PMID 9610397.
• Pushkin A, Abuladze N, Lee I, et al. (1999). "Mapping of the human NBC3 (SLC4A7) gene to chromosome 3p22". Genomics. 57 (2): 321–2. doi:10.1006/geno.1999.5781. PMID 10198178.
• Pushkin A, Abuladze N, Lee I, et al. (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi:10.1074/jbc.274.23.16569. PMID 10347222.
• Pushkin A, Yip KP, Clark I, et al. (2000). "NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase". Am. J. Physiol. 277 (6 Pt 2): F974–81. doi:10.1152/ajprenal.1999.277.6.F974. PMID 10600945. S2CID 4457223.
• Park M, Ko SB, Choi JY, et al. (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.
• Loiselle FB, Jaschke P, Casey JR (2004). "Structural and functional characterization of the human NBC3 sodium/bicarbonate co-transporter carboxyl-terminal cytoplasmic domain". Mol. Membr. Biol. 20 (4): 307–17. doi:10.1080/0968768031000122520. PMID 14578046. S2CID 30980041.
• Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710. S2CID 16522705.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Reiners J, van Wijk E, Märker T, et al. (2006). "Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2". Hum. Mol. Genet. 14 (24): 3933–43. doi:10.1093/hmg/ddi417. PMID 16301216.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.