SLFN5

Schlafen family member 5 is a protein that in humans is encoded by the SLFN5 gene.

SLFN5
Identifiers
Aliases	SLFN5, schlafen family member 5
External IDs	OMIM: 614952; MGI: 1329004; HomoloGene: 18839; GeneCards: SLFN5; OMA:SLFN5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q12 Start 35,243,071 bp End 35,273,655 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 C Start 82,842,175 bp End 82,855,666 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura pancreatic ductal cell superficial temporal artery parietal pleura pylorus cardia buccal mucosa cell nasal epithelium tendon of biceps brachii nipple Top expressed in muscle of thigh white adipose tissue right lung myocardium of ventricle esophagus granulocyte subcutaneous adipose tissue soleus muscle stroma of bone marrow extraocular muscle More reference expression data BioGPS n/a
Gene ontology Molecular function ATP binding nucleotide binding Cellular component nucleus Biological process cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 162394 327978 Ensembl ENSG00000166750 ENSMUSG00000054404 UniProt Q08AF3 Q8CBA2 RefSeq (mRNA) NM_144975 NM_001330183 NM_183201 RefSeq (protein) NP_001317112 NP_659412 NP_899024 Location (UCSC) Chr 17: 35.24 – 35.27 Mb Chr 11: 82.84 – 82.86 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Katsoulidis E, Mavrommatis E, Woodard J, Shields MA, Sassano A, Carayol N, Sawicki KT, Munshi HG, Platanias LC (December 2010). "Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells". J. Biol. Chem. 285 (51): 40333–41. doi:10.1074/jbc.M110.151076. PMC 3001013. PMID 20956525.
• Sassano A, Mavrommatis E, Arslan AD, Kroczynska B, Beauchamp EM, Khuon S, Chew TL, Green KJ, Munshi HG, Verma AK, Platanias LC (August 2015). "Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells". Mol. Cell. Biol. 35 (15): 2684–98. doi:10.1128/MCB.00019-15. PMC 4524119. PMID 26012550.
• Companioni Nápoles O, Tsao AC, Sanz-Anquela JM, Sala N, Bonet C, Pardo ML, Ding L, Simo O, Saqui-Salces M, Blanco VP, Gonzalez CA, Merchant JL (January 2017). "SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer". J. Gastroenterol. 52 (1): 39–49. doi:10.1007/s00535-016-1202-4. PMC 5045746. PMID 27032393.
• Arslan AD, Sassano A, Saleiro D, Lisowski P, Kosciuczuk EM, Fischietti M, Eckerdt F, Fish EN, Platanias LC (October 2017). "Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma". Oncogene. 36 (43): 6006–6019. doi:10.1038/onc.2017.205. PMC 5821504. PMID 28671669.