SMPD3

Neutral Sphingomyelinase2 is an enzyme that in humans is encoded by the SMPD3 gene.

SMPD3
Identifiers
Aliases	SMPD3, NSMASE2, sphingomyelin phosphodiesterase 3
External IDs	OMIM: 605777; MGI: 1927578; HomoloGene: 10260; GeneCards: SMPD3; OMA:SMPD3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 68,358,327 bp End 68,448,508 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 106,979,180 bp End 107,064,620 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia duodenum periodontal fiber thymus jejunal mucosa ganglionic eminence mucosa of transverse colon putamen right hemisphere of cerebellum rectum Top expressed in membranous bone Dermatocranium calvaria mandible maxilla lumbar spinal ganglion olfactory tubercle long bone body of femur molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sphingomyelin phosphodiesterase activity metal ion binding hydrolase activity protein binding neutral sphingomyelin phosphodiesterase activity phospholipase activity Cellular component Golgi apparatus membrane Golgi membrane Golgi cis cisterna plasma membrane cytoplasm Biological process positive regulation of ceramide biosynthetic process lipid metabolism multicellular organism development sphingomyelin catabolic process peptide hormone secretion hematopoietic progenitor cell differentiation cell cycle positive regulation of exosomal secretion sphingomyelin metabolic process sphingolipid metabolic process skeletal system development endochondral ossification chondrocyte development regulation of leukocyte migration bone mineralization BMP signaling pathway multicellular organism growth protein kinase B signaling cartilage development protein homooligomerization bone development regulation of cartilage development cellular response to redox state bone growth cellular response to peptide ossification regulation of protein phosphorylation chondrocyte development involved in endochondral bone morphogenesis ceramide metabolic process glycosphingolipid metabolic process signal transduction polysaccharide transport lung development collagen metabolic process cellular response to reactive oxygen species positive regulation of mitotic nuclear division platelet-derived growth factor receptor signaling pathway lung alveolus development positive regulation of smooth muscle cell proliferation respiratory system development cellular response to hydrogen peroxide G1 to G0 transition cellular response to magnesium ion cellular response to tumor necrosis factor DNA biosynthetic process extracellular matrix assembly sphingolipid mediated signaling pathway dentinogenesis mitotic nuclear division cellular response to oxidised low-density lipoprotein particle stimulus regulation of hyaluronan biosynthetic process negative regulation of hyaluronan biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55512 58994 Ensembl ENSG00000103056 ENSMUSG00000031906 UniProt Q9NY59 Q9JJY3 RefSeq (mRNA) NM_018667 NM_021491 RefSeq (protein) NP_061137 NP_067466 Location (UCSC) Chr 16: 68.36 – 68.45 Mb Chr 8: 106.98 – 107.06 Mb PubMed search
Wikidata
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Further reading

• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Marchesini N, Luberto C, Hannun YA (2003). "Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism". J. Biol. Chem. 278 (16): 13775–83. doi:10.1074/jbc.M212262200. PMID 12566438.
• Miura Y, Gotoh E, Nara F, et al. (2004). "Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases". FEBS Lett. 557 (1–3): 288–92. doi:10.1016/S0014-5793(03)01523-0. PMID 14741383. S2CID 34738077.
• Marchesini N, Osta W, Bielawski J, et al. (2004). "Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells". J. Biol. Chem. 279 (24): 25101–11. doi:10.1074/jbc.M313662200. PMID 15051724.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jana A, Pahan K (2005). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase". J. Neurosci. 24 (43): 9531–40. doi:10.1523/JNEUROSCI.3085-04.2004. PMC 1955476. PMID 15509740.
• Krut O, Wiegmann K, Kashkar H, et al. (2006). "Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein". J. Biol. Chem. 281 (19): 13784–93. doi:10.1074/jbc.M511306200. PMID 16517606.
• Levy M, Castillo SS, Goldkorn T (2006). "nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis". Biochem. Biophys. Res. Commun. 344 (3): 900–5. doi:10.1016/j.bbrc.2006.04.013. PMC 4370275. PMID 16631623.
• Clarke CJ, Truong TG, Hannun YA (2007). "Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2". J. Biol. Chem. 282 (2): 1384–96. doi:10.1074/jbc.M609216200. PMID 17085432.
• Tani M, Hannun YA (2007). "Analysis of membrane topology of neutral sphingomyelinase 2". FEBS Lett. 581 (7): 1323–8. doi:10.1016/j.febslet.2007.02.046. PMC 1868537. PMID 17349629.
• Filosto S, Fry W, Knowlton A, Goldkorn T (2010). "Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)". J. Biol. Chem. 285 (14): 10213–22. doi:10.1074/jbc.M109.069963. PMC 2856226. PMID 20106976.