SNTG1

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.

SNTG1
Identifiers
Aliases	SNTG1, G1SYN, SYN4, syntrophin gamma 1
External IDs	OMIM: 608714; MGI: 1918346; HomoloGene: 56834; GeneCards: SNTG1; OMA:SNTG1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q11.21 Start 49,909,789 bp End 50,796,692 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 A1-A2 Start 8,361,475 bp End 9,299,878 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 primary visual cortex middle temporal gyrus ventricular zone testicle dorsolateral prefrontal cortex Brodmann area 9 nucleus accumbens prefrontal cortex caudate nucleus Top expressed in lumbar subsegment of spinal cord dentate gyrus of hippocampal formation granule cell spermatid primary visual cortex superior frontal gyrus neural layer of retina facial motor nucleus embryo cerebellar cortex hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein C-terminus binding structural molecule activity Cellular component cytoplasm ruffle membrane syntrophin complex cytoskeleton nucleus dystrophin-associated glycoprotein complex Biological process cell communication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54212 71096 Ensembl ENSG00000147481 ENSMUSG00000025909 UniProt Q9NSN8 Q925E1 RefSeq (mRNA) NM_001287813 NM_001287814 NM_018967 NM_001321773 NM_001321775 NM_001321776 NM_001321777 NM_001321778 NM_001290390 NM_001290392 NM_001290393 NM_027671 RefSeq (protein) NP_001274742 NP_001274743 NP_001308702 NP_001308704 NP_001308705 NP_001308706 NP_001308707 NP_061840 NP_001274742.1 NP_061840.1 NP_001308702.1 NP_001277319 NP_001277321 NP_001277322 NP_081947 Location (UCSC) Chr 8: 49.91 – 50.8 Mb Chr 1: 8.36 – 9.3 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This gene is specifically expressed in the brain. Transcript variants for this gene have been described, but their full-length nature has not been determined.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Hogan A, Shepherd L, Chabot J, et al. (2001). "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions". J. Biol. Chem. 276 (28): 26526–33. doi:10.1074/jbc.M104156200. PMID 11352924.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Widberg CH, Bryant NJ, Girotti M, et al. (2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
• Buxton P, Zhang XM, Walsh B, et al. (2004). "Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells". Biochem. J. 375 (Pt 2): 433–40. doi:10.1042/BJ20030427. PMC 1223698. PMID 12877659.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Chen Z, Hague C, Hall RA, Minneman KP (2006). "Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction". J. Biol. Chem. 281 (18): 12414–20. doi:10.1074/jbc.M508651200. PMID 16533813.