SOX7

SRY-box 7 is a protein that in humans is encoded by the SOX7 gene.

SOX7
Identifiers
Aliases	SOX7, SRY-box 7, SRY-box transcription factor 7
External IDs	OMIM: 612202; MGI: 98369; HomoloGene: 7949; GeneCards: SOX7; OMA:SOX7 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p23.1 Start 10,723,768 bp End 10,730,511 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D1 Start 64,181,122 bp End 64,188,181 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta vagina apex of heart skin of abdomen upper lobe of left lung left ventricle testicle subcutaneous adipose tissue skin of leg olfactory zone of nasal mucosa Top expressed in right lung lobe cardiac muscle tissue of left ventricle left lung lobe lip atrium atrioventricular valve urethra renal vein extraocular muscle endocardial cushion More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding DNA-binding transcription factor activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus nucleoplasm Biological process regulation of canonical Wnt signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic process endoderm formation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of cell population proliferation regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83595 20680 Ensembl ENSG00000171056 ENSG00000285438 ENSMUSG00000063060 UniProt Q9BT81 P40646 RefSeq (mRNA) NM_031439 NM_011446 RefSeq (protein) NP_113627 NP_035576 Location (UCSC) Chr 8: 10.72 – 10.73 Mb Chr 14: 64.18 – 64.19 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008].

SOX7 is a transcription factor that comes from the SRY-related HMG-Box family of transcription factors. These factors play a significant developmental role in regulating processes such as hematopoiesis, vasculogenesis, and cardiogenesis during the development of the embryo. Additionally, SOX7 is unique as it has been shown to also have tumor-suppressive effects, and downregulation of this gene has been seen in many forms of cancer. SOX7 as well as SOX17 and SOX18 have been known to work together to play a significant role in cardiovascular development, but continued research continues to identify SOX7 as playing a significant role in cancerous tumor suppression. Scientists discovered that the homozygous deletion of the second exon in SOX7 was embryonically lethal, and a heterozygous deletion resulted in a congenital diaphragmatic hernia forming. Continued research needs to be done to fully understand the mechanism behind SOX7’s tumor-suppressing characteristics, and hopefully, utilize that to find new and improved cancer treatments for the future. Overall SOX7 is a very interesting gene that plays a significant role in a variety of vital processes embryonically and postnatally and understanding the mechanisms for how this SRY family gene interacts with its surrounding tissues and cells can lead to better treatments for defects within SOX7 in the future.

References

Stovall, Daniel B et al. “SOX7: from a developmental regulator to an emerging tumor suppressor.” Histology and histopathology vol. 29,4 (2014): 439-45. doi:10.14670/HH-29.10.439

Further reading

• Takash W, Cañizares J, Bonneaud N, Poulat F, Mattéi MG, Jay P, Berta P (November 2001). "SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling". Nucleic Acids Res. 29 (21): 4274–83. doi:10.1093/nar/29.21.4274. PMC 60197. PMID 11691915.
• Séguin CA, Draper JS, Nagy A, Rossant J (August 2008). "Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells". Cell Stem Cell. 3 (2): 182–95. doi:10.1016/j.stem.2008.06.018. PMID 18682240.
• Guo L, Zhong D, Lau S, Liu X, Dong XY, Sun X, Yang VW, Vertino PM, Moreno CS, Varma V, Dong JT, Zhou W (September 2008). "Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells". Mol. Cancer Res. 6 (9): 1421–30. doi:10.1158/1541-7786.MCR-07-2175. PMC 2652859. PMID 18819930.
• Semb H (October 2008). "Expandable endodermal progenitors: new tools to explore endoderm and its derivatives". Cell Stem Cell. 3 (4): 355–6. doi:10.1016/j.stem.2008.09.010. PMID 18940723.
• Zhang Y, Huang S, Dong W, Li L, Feng Y, Pan L, Han Z, Wang X, Ren G, Su D, Huang B, Lu J (May 2009). "SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells". Cancer Lett. 277 (1): 29–37. doi:10.1016/j.canlet.2008.11.014. PMID 19108950.
• Zhou X, Huang SY, Feng JX, Gao YY, Zhao L, Lu J, Huang BQ, Zhang Y (November 2011). "SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells". World J. Gastroenterol. 17 (44): 4922–7. doi:10.3748/wjg.v17.i44.4922. PMC 3235637. PMID 22171135.
• Fan R, Zhang LY, Wang H, Yang B, Han T, Zhao XL, Wang W, Wang XQ, Lin GW (June 2012). "Methylation of the CpG island near SOX7 gene promoter is correlated with the poor prognosis of patients with myelodysplastic syndrome". Tohoku J. Exp. Med. 227 (2): 119–28. doi:10.1620/tjem.227.119. PMID 22706399.
• Li B, Ge Z, Song S, Zhang S, Yan H, Huang B, Zhang Y (October 2012). "Decreased expression of SOX7 is correlated with poor prognosis in lung adenocarcinoma patients". Pathol. Oncol. Res. 18 (4): 1039–45. doi:10.1007/s12253-012-9542-8. PMID 22777918. S2CID 10156272.
• Chan DW, Mak CS, Leung TH, Chan KK, Ngan HY (December 2012). "Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer". Oncotarget. 3 (12): 1546–56. doi:10.18632/oncotarget.667. PMC 3681493. PMID 23295859.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.