SP140 (gene)

SP140 nuclear body protein is a protein that in humans is encoded by the SP140 gene.

SP140
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2MD7, 2MD8
Identifiers
Aliases	SP140, LYSP100, LYSP100-A, LYSP100-B, SP140 nuclear body protein
External IDs	OMIM: 608602; MGI: 3702467; HomoloGene: 128391; GeneCards: SP140; OMA:SP140 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.1 Start 230,203,110 bp End 230,313,215 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C5 Start 85,600,378 bp End 85,645,037 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node granulocyte spleen appendix blood monocyte tonsil bone marrow cells testicle epithelium of nasopharynx Top expressed in blastocyst granulocyte spleen bone marrow thymus morula urinary bladder white adipose tissue zone of skin lung More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding metal ion binding Cellular component cytoplasm PML body nuclear envelope mitochondrion nucleus nucleoplasm fibrillar center nuclear body Biological process defense response regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11262 434484 Ensembl ENSG00000079263 ENSMUSG00000070031 UniProt Q13342 n/a RefSeq (mRNA) NM_001005176 NM_001278451 NM_001278452 NM_001278453 NM_007237 NM_001013817 RefSeq (protein) NP_001005176 NP_001265380 NP_001265381 NP_001265382 NP_009168 n/a Location (UCSC) Chr 2: 230.2 – 230.31 Mb Chr 1: 85.6 – 85.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Madani N, Millette R, Platt EJ, Marin M, Kozak SL, Bloch DB, Kabat D (2002). "Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1". J. Virol. 76 (21): 11133–8. doi:10.1128/jvi.76.21.11133-11138.2002. PMC 136615. PMID 12368356.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Nuclear body protein SP140