SPC24

Kinetochore protein Spc24 is a protein that in humans is encoded by the SPC24 gene.

SPC24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VE7, 3IZ0
Identifiers
Aliases	SPC24, SPBC24, NDC80 kinetochore complex component, SPC24 component of NDC80 kinetochore complex
External IDs	OMIM: 609394; MGI: 1914879; HomoloGene: 12166; GeneCards: SPC24; OMA:SPC24 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 11,131,520 bp End 11,155,808 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A3 Start 21,666,738 bp End 21,671,599 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence stromal cell of endometrium trabecular bone testicle bone marrow gonad mucosa of transverse colon bone marrow cells appendix Top expressed in hand yolk sac embryo embryo epiblast ventricular zone thymus morula primitive streak Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytosol Ndc80 complex nucleolus chromosome, centromeric region nucleus kinetochore chromosome Biological process cell division cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 147841 67629 Ensembl ENSG00000161888 ENSMUSG00000074476 UniProt Q8NBT2 Q9D083 RefSeq (mRNA) NM_182513 NM_001317031 NM_001317032 NM_001317033 NM_026282 NM_001357331 RefSeq (protein) NP_001303960 NP_001303961 NP_001303962 NP_872319 NP_080558 NP_001344260 Location (UCSC) Chr 19: 11.13 – 11.16 Mb Chr 9: 21.67 – 21.67 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ (June 2005). "Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores". Current Biology. 15 (12): 1078–89. doi:10.1016/j.cub.2005.05.026. PMID 15964272. S2CID 14251198.
• Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A (August 2005). "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore". The Journal of Biological Chemistry. 280 (32): 29088–95. doi:10.1074/jbc.M504070200. PMID 15961401.
• Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
• McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT (January 2004). "The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment". Current Biology. 14 (2): 131–7. doi:10.1016/j.cub.2003.12.058. PMID 14738735. S2CID 16533093.
• Bharadwaj R, Qi W, Yu H (March 2004). "Identification of two novel components of the human NDC80 kinetochore complex". The Journal of Biological Chemistry. 279 (13): 13076–85. doi:10.1074/jbc.M310224200. PMID 14699129.