SPK may refer to:
- SPK (band), Australia
- SPK, Soviet cosmonaut maneuvering unit
- Simultaneous pancreas-kidney transplant, a type of pancreas transplantation
- Socialist Patients' Collective (German: Sozialistisches Patientenkollektiv)
- Stiftung Preußischer Kulturbesitz, the Prussian Cultural Heritage Foundation
- Strategic Plan Campine (Dutch: Strategisch Plan Kempen)
- Sutton Parkway railway station's station code
This disambiguation page lists articles associated with the title SPK.
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