Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene.[5]

SPPL2B
Identifiers
AliasesSPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B
External IDsOMIM: 608239; MGI: 1920468; HomoloGene: 10605; GeneCards: SPPL2B; OMA:SPPL2B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077238
NM_152988

NM_175195
NM_001358803
NM_001358804

RefSeq (protein)

NP_001070706
NP_694533

NP_780404
NP_001345732
NP_001345733

Location (UCSC)Chr 19: 2.33 – 2.36 MbChr 10: 80.69 – 80.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the signal peptide peptidase-like protease (SPPL) family with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This enzyme localizes to endosomes, lysosomes, and the plasma membrane. This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells.[6][7] SPPL2b also modulates APP cleavage and Aβ production.[8] Multiple transcript variants encoding different isoforms have been found for this gene.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000005206Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035206Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SPPL2B signal peptide peptidase-like 2B".
  6. ^ Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production". Nat. Cell Biol. 8 (8): 843–8. doi:10.1038/ncb1440. PMID 16829952. S2CID 129089.
  7. ^ Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b". Nat. Cell Biol. 8 (8): 894–6. doi:10.1038/ncb1450. PMID 16829951. S2CID 23712486.
  8. ^ Maccioni, Riccardo; Travisan, Caterina; Badman, Jack; Zerial, Stefania; Wagener, Annika; Andrade-Talavera, Yuniesky; Picciau, Federico; Grassi, Caterina; Chen, Gefei; Lemoine, Laetitia; Fisahn, André; Jiang, Richeng; Fluhrer, Regina; Mentrup, Torben; Schröder, Bernd (April 2024). "Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease". Progress in Neurobiology. 235: 102585. doi:10.1016/j.pneurobio.2024.102585.

Further reading

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