SPRY1

Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene.

SPRY1
Identifiers
Aliases	SPRY1, hsprouty RTK signaling antagonist 1
External IDs	OMIM: 602465; MGI: 1345139; HomoloGene: 4266; GeneCards: SPRY1; OMA:SPRY1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q28.1 Start 123,396,795 bp End 123,403,760 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 B Start 37,694,096 bp End 37,698,747 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium vena cava gallbladder parietal pleura epithelium of colon subcutaneous adipose tissue canal of the cervix skin of leg left uterine tube left lobe of thyroid gland Top expressed in secondary oocyte tail of embryo lip primary oocyte lung esophagus quadriceps femoris muscle right kidney zone of skin adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component Golgi apparatus membrane plasma membrane nucleoplasm cytoplasm cytosol Biological process ureteric bud development negative regulation of neurotrophin TRK receptor signaling pathway negative regulation of epidermal growth factor receptor signaling pathway organ induction bud elongation involved in lung branching negative regulation of Ras protein signal transduction multicellular organism development negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of GTPase activity regulation of signal transduction negative regulation of MAP kinase activity establishment of mitotic spindle orientation metanephros development negative regulation of cell population proliferation negative regulation of ERK1 and ERK2 cascade epithelial to mesenchymal transition involved in cardiac fibroblast development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10252 24063 Ensembl ENSG00000164056 ENSMUSG00000037211 UniProt O43609 Q9QXV9 RefSeq (mRNA) NM_001258038 NM_001258039 NM_005841 NM_199327 NM_001375410 NM_011896 NM_001305440 NM_001305441 NM_001305442 RefSeq (protein) NP_001244967 NP_001244968 NP_005832 NP_955359 NP_001362339 NP_001292369 NP_001292370 NP_001292371 NP_036026 Location (UCSC) Chr 4: 123.4 – 123.4 Mb Chr 3: 37.69 – 37.7 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Neurofibromin 1
• SPRED1

Further reading

• Lim J, Wong ES, Ong SH, Yusoff P, Low BC, Guy GR (October 2000). "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain". The Journal of Biological Chemistry. 275 (42): 32837–45. doi:10.1074/jbc.M002156200. PMID 10887178.
• Egan JE, Hall AB, Yatsula BA, Bar-Sagi D (April 2002). "The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins". Proceedings of the National Academy of Sciences of the United States of America. 99 (9): 6041–6. Bibcode:2002PNAS...99.6041E. doi:10.1073/pnas.052090899. PMC 122898. PMID 11983899.
• Hanafusa H, Torii S, Yasunaga T, Nishida E (November 2002). "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway". Nature Cell Biology. 4 (11): 850–8. doi:10.1038/ncb867. PMID 12402043. S2CID 31064800.
• Di Y, Li J, Zhang Y, He X, Lu H, Xu D, et al. (June 2003). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins". Journal of Biochemistry. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
• Wang L, Ji C, Wu H, Xu J, Wu Q, Dai J, et al. (November 2003). "Identification and expression analysis of a novel splice variant of human Sprouty1 gene". International Journal of Molecular Medicine. 12 (5): 783–7. doi:10.3892/ijmm.12.5.783. PMID 14533010.
• Anteby EY, Natanson-Yaron S, Greenfield C, Goldman-Wohl D, Haimov-Kochman R, Holzer H, Yagel S (July 2005). "Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching". Placenta. 26 (6): 476–83. doi:10.1016/j.placenta.2004.08.008. PMID 15950061.
• Cabrita MA, Jäggi F, Widjaja SP, Christofori G (September 2006). "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry. 281 (39): 29201–12. doi:10.1074/jbc.M603921200. PMID 16877379.
• Fritzsche S, Kenzelmann M, Hoffmann MJ, Müller M, Engers R, Gröne HJ, Schulz WA (September 2006). "Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma". Endocrine-Related Cancer. 13 (3): 839–49. doi:10.1677/erc.1.01190. PMID 16954433.
• Schaaf G, Hamdi M, Zwijnenburg D, Lakeman A, Geerts D, Versteeg R, Kool M (January 2010). "Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene". Cancer Research. 70 (2): 762–71. doi:10.1158/0008-5472.CAN-09-2532. PMID 20068162.
• Charles NJ, Huebert RC, Lee S, Adhikari N, Polster S, Rider JE, et al. (September 2010). "Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function". Molecular and Cellular Biochemistry. 342 (1–2): 57–62. doi:10.1007/s11010-010-0468-8. PMC 2923832. PMID 20461448.

External links

• SPRY1 human gene location in the UCSC Genome Browser.
• SPRY1 human gene details in the UCSC Genome Browser.