SPRY4

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.

SPRY4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BUN
Identifiers
Aliases	SPRY4, HH17, sprouty RTK signaling antagonist 4
External IDs	OMIM: 607984; MGI: 1345144; HomoloGene: 8042; GeneCards: SPRY4; OMA:SPRY4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.3 Start 142,310,427 bp End 142,326,455 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18 B3|18 20.5 cM Start 38,719,300 bp End 38,734,468 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left coronary artery right lung ascending aorta upper lobe of left lung Descending thoracic aorta cartilage tissue right coronary artery lower lobe of lung tibial arteries left adrenal gland Top expressed in secondary oocyte primary oocyte tail of embryo zygote left lung lobe lumbar spinal ganglion entorhinal cortex perirhinal cortex Ileal epithelium nasolacrimal duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component ruffle membrane plasma membrane cell projection membrane focal adhesion cytoplasm cytosol Biological process multicellular organism development negative regulation of ERK1 and ERK2 cascade regulation of signal transduction negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of MAP kinase activity negative regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81848 24066 Ensembl ENSG00000187678 ENSMUSG00000024427 UniProt Q9C004 Q9WTP2 RefSeq (mRNA) NM_001127496 NM_001293289 NM_001293290 NM_030964 NM_011898 RefSeq (protein) NP_001120968 NP_001280218 NP_001280219 NP_112226 NP_036028 Location (UCSC) Chr 5: 142.31 – 142.33 Mb Chr 18: 38.72 – 38.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).

Interactions

SPRY4 has been shown to interact with TESK1.

See also

• MAPK signaling pathway
• Ras subfamily

Further reading

• Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D (2008). "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping". BMC Psychiatry. 8: 11. doi:10.1186/1471-244X-8-11. PMC 2268687. PMID 18298822.
• Cabrita MA, Jäggi F, Widjaja SP, Christofori G (Sep 2006). "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry. 281 (39): 29201–12. doi:10.1074/jbc.M603921200. PMID 16877379.
• Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B (May 2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer". The Prostate. 66 (6): 613–24. doi:10.1002/pros.20353. PMID 16388505. S2CID 43803094.
• Ding W, Bellusci S, Shi W, Warburton D (Jul 2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis". American Journal of Physiology. Lung Cellular and Molecular Physiology. 287 (1): L52-9. doi:10.1152/ajplung.00430.2003. PMID 14977631.
• Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology. 5 (5): 427–32. doi:10.1038/ncb978. PMID 12717443. S2CID 33846459.
• Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)