Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the SSX2IP gene .[ 5] It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation.[ 6] [ 7] [ 8] [ 9] [ 10] The SSX2IP-WDR8 complex additionally promotes ciliary vesicle docking during ciliogenesis.[ 11] [ 12]
^ a b c GRCh38: Ensembl release 89: ENSG00000117155 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036825 – Ensembl , May 2017
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^ Yukawa M, Ikebe C, Toda T (May 2015). "The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies" . The Journal of Cell Biology . 209 (4): 549–62. doi :10.1083/jcb.201412111 . PMC 4442821 . PMID 25987607 .
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^ Hori A, Peddie CJ, Collinson LM, Toda T (June 2015). "Centriolar satellite- and hMsd1/SSX2IP-dependent microtubule anchoring is critical for centriole assembly" . Molecular Biology of the Cell . 26 (11): 2005–19. doi :10.1091/mbc.E14-11-1561 . PMC 4472012 . PMID 25833712 .
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^ Klinger M, Wang W, Kuhns S, Bärenz F, Dräger-Meurer S, Pereira G, Gruss OJ (February 2014). "The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone" . Molecular Biology of the Cell . 25 (4): 495–507. doi :10.1091/mbc.E13-09-0526 . PMC 3923641 . PMID 24356449 .
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